AI Article Synopsis
- * Their structures were determined using various analytical methods like UV, IR, NMR, HRESIMS, and CD spectroscopy.
- * The compounds showed selective inhibitory activity against DGAT1 with IC values between 60.4 and 84.6 μM, and potential binding sites for one compound were predicted through molecular docking.
Article Abstract
Six new sesquineolignans (1-6), have been isolated and elucidated from the stems of Akebia quinate together with five known analogues (7-11). Their structures were elucidated on the basis of comprehensive analysis of UV, IR, NMR, HRESIMS and CD spectroscopy experiments. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds 1-11 were found to exhibit selective inhibitory activity on DGAT1 with IC values ranging from 60.4 ± 1.3 to 84.6 ± 1.3 μM. Besides, the potential binding sites of 1 were predicted by molecular docking.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.fitote.2024.106221 | DOI Listing |
Publication Analysis
Top Keywords
stems akebia
8
akebia quinate
8
inhibitory activity
8
activity dgat1
8
sesquineolignans stems
4
quinate diacylglycerol
4
diacylglycerol acyltransferase
4
acyltransferase activity
4
activity sesquineolignans
4
sesquineolignans 1-6
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!