AI Article Synopsis
- This research focuses on finding non-invasive markers to predict the recurrence of autoimmune liver diseases in children, which traditionally require invasive liver biopsies for monitoring.
- The study analyzed blood serum from 80 children with autoimmune liver conditions, observing the relationship between monocyte subpopulations and disease activity through flow cytometry and other markers.
- Results showed that specific monocyte types, particularly intermediate CD14++/CD16+ and non-classical CD14lowCD16+ monocytes, are linked to disease activity and could serve as valuable biomarkers for predicting relapses.
Article Abstract
Background: Patients with autoimmune liver diseases require individualized long-term immunosuppressive therapy, whose discontinuation is possible after complete histological remission and that requires repeated liver biopsy. In view of this, the search for non-invasive markers is essential for patients with autoimmune liver disease.
Purpose: The purpose of this research is to assess the possibility of predicting the recurrence of autoimmune liver disease in children.
Method: The biological material used in the study was blood serum from 80 children diagnosed with autoimmune hepatitis and autoimmune sclerosing cholangitis. Patients were divided into four groups according to disease activity and therapeutic approach.
Results: The percentage of monocyte subpopulations was determined by flow cytometry, and disease activity, inflammation, and fibrosis markers were analyzed to study the relationship and diagnostic value of the parameters studied in detail. The results of the study indicate a significant relationship between disease activity and changes in the distribution of the percentage of monocyte subpopulations in the blood. The percentage of intermediate CD14++/CD16+ monocytes was found to correlate with disease activity, and non-classical CD14lowCD16+ monocytes were found to be of high diagnostic value in the diagnosis of disease relapse.
Conclusions: These findings not only expand the understanding of the pathogenesis of autoimmune liver disease but also point to the prospects of using monocyte subpopulations as potential biomarkers for predicting relapse, contributing to the development of more effective clinical management strategies.
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| http://dx.doi.org/10.1016/j.prp.2024.155622 | DOI Listing |
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