Precise modulation of cell activity using sono-responsive nano-transducers.

Biomaterials

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, 999077, PR China. Electronic address:

Published: March 2025

AI Article Synopsis

  • - Ultrasound can deeply penetrate tissues to non-invasively influence cellular activities, making it a valuable tool in biomedical research.
  • - Combining ultrasound with nanomaterials allows for precise control over these activities using various stimuli like electric, optical, and chemical signals at a localized level.
  • - The article reviews the latest advancements in ultrasound technology paired with nanomaterials and discusses its potential applications in biology and medicine for research, diagnostics, and therapeutic purposes.

Article Abstract

Ultrasound, as a form of mechanical energy, possesses a distinctive ability to deeply penetrate tissues, allowing for non-invasive manipulation of cellular activities. Utilizing nanomaterials in conjunction with ultrasound has enabled simple, efficient, spatiotemporally controllable, and minimally invasive regulation of cellular activities with ultrasound-generated electric, optical, acoustic, or chemical stimuli at the localized nanomaterials interface. This technology allows for precise and localized regulation of cellular activities, which is essential for studying and understanding complex biological processes, and also provides new opportunities for research, diagnostics, and therapeutics in the fields of biology and medicine. In this article, we review the state-of-the-art and ongoing developments in nanomaterials-enabled ultrasound cellular modulation, highlighting potential applications and advancements achieved through the integration of sono-responsive nanomaterials with ultrasound.

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Source
http://dx.doi.org/10.1016/j.biomaterials.2024.122857DOI Listing

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