Purpose: This work aimed to investigate the effects of Tanshinone IIA (Tan IIA) on myocardial cell (MC) apoptosis in a rat model of heart failure (HF).
Methods: Tan IIA was extracted from Salvia miltiorrhiza Bunge (SMB) using an ethanol reflux method. Fifty rats were randomly divided into five groups: sham (no treatment), mod (HF model establishment), low dose (LD: 0.1 mL/kg Tan IIA), medium dose (MD: 0.3 mL/kg Tan IIA), and high dose (HD: 0.5 mL/kg Tan IIA), with 10 rats in each group. The effects of different doses of Tan IIA on cardiac function, MC apoptosis, and the levels of proteins associated with the PI3K/Akt/mTOR signaling pathway were compared.
Results: Mod group showed a significant decrease in systolic arterial pressure, mean arterial pressure, heart rate, left ventricular systolic pressure, left ventricular ejection fraction, left ventricular fractional shortening, and the levels of p-PI3K, p-Akt, and p-mTOR proteins versus sham group (p < 0.05). Additionally, the left ventricular end-diastolic diameter (LVIDd), end-systolic diameter, diastolic pressure, and MC apoptosis were significantly increased (p < 0.05). LD, MD, and HD groups exhibited significant improvements across various indicators of cardiac function and MC apoptosis versus mod group (p < 0.05).
Conclusions: Tan IIA may improve cardiac function and inhibit MC apoptosis in rats with HF by modulating the PI3K/Akt/mTOR signaling pathway.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441121 | PMC |
| http://dx.doi.org/10.1590/acb396524 | DOI Listing |
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- The respiratory system is vital for oxygen absorption and carbon dioxide expulsion, helping to maintain the body's acid-base balance and metabolic stability.
- The outbreak of COVID-19 has highlighted the need for new treatments for respiratory diseases, leading to renewed interest in Tanshinone IIA, a bioactive compound traditionally used for heart diseases.
- Research shows Tanshinone IIA has various therapeutic effects, including anti-inflammatory and anti-cancer properties, and it shows promise in treating conditions like asthma and lung cancer, making it a valuable focus for future studies.
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