AI Article Synopsis
- - A 61-year-old male experienced a persistent fever for three months, leading to a diagnosis of hemophagocytic lymphohistiocytosis after a liver biopsy and positron-emission tomography showed abnormal lesions in the liver.
- - Common symptoms of this condition include fever, an enlarged spleen, high levels of ferritin and triglycerides, elevated liver enzymes, and signs of hemophagocytosis in the bone marrow.
- - Treatment options generally involve systemic corticosteroids, chemotherapy, cyclosporine, or hematopoietic stem cell transplantation, but there's a concern that this diagnosis can be overlooked in resource-limited settings like Nepal, so doctors should consider it in cases of unexplained fever.
Article Abstract
A case of a 61-year male presented with chief complaints of fever for three months. Diagnosis of hemophagocytic lymphohistiocytosis was made after liver biopsy when Positron-Emission Tomography revealed multiple fluoro deoxy glucose avid lesions in the liver. The patient of this disease typically presents with fever, splenomegaly, hyperferritinemia, hypertriglyceridemia, raised liver enzymes, and marrow features suggestive of hemophagocytosis. The treatment is usually systemic corticosteroids, chemotherapy with etoposide, cyclosporine, or hematopoietic stem cell transplantation, depending on the cause. A diagnosis like hemophagocytic lymphohistiocytosis can easily be missed in developing countries with low resources like Nepal. Hence, this disease should be suspected in patients presenting with pyrexia of unknown origin by treating physicians.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11185309 | PMC |
| http://dx.doi.org/10.31729/jnma.8626 | DOI Listing |
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