AI Article Synopsis

  • Bioelectronic implants with soft mechanics and high biocompatibility show great promise for improving medical technologies by recording signals and providing treatments directly in the body.
  • Despite their potential, they still face challenges like high impedance at the bioelectronic-tissue interface, which affects their performance.
  • The introduction of OBXene, a new material with low impedance and piezoelectric properties, has led to the development of a cardiac patch that enables advanced heart mapping and pacing in animal models while being wireless and battery-free for long-term use.

Article Abstract

Bioelectronic implants featuring soft mechanics, excellent biocompatibility, and outstanding electrical performance hold promising potential to revolutionize implantable technology. These biomedical implants can record electrophysiological signals and execute direct therapeutic interventions within internal organs, offering transformative potential in the diagnosis, monitoring, and treatment of various pathological conditions. However, challenges remain in improving excessive impedance at the bioelectronic-tissue interface and thus the efficacy of electrophysiological signaling and intervention. Here, we devise orbit symmetry breaking in MXene (a low-cost scalability, biocompatible, and conductive two dimensionally layered material, which we refer to as OBXene), which exhibits low bioelectronic-tissue impedance, originating from the out-of-plane charge transfer. Furthermore, the Schottky-induced piezoelectricity stemming from the asymmetric orbital configuration of OBXene facilitates interlayered charge transport in the device. We report an OBXene-based cardiac patch applied on the left ventricular epicardium of both rodent and porcine models to enable spatiotemporal epicardium mapping and pacing while coupling the wireless and battery-free operation for long-term real-time recording and closed-loop stimulation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446273PMC
http://dx.doi.org/10.1126/sciadv.adp8866DOI Listing

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