This article proposes a nonaugmented method for investigating the minimal observability problem of Boolean networks (BNs). This method can be applied to more general BNs and reduce the computational and space complexity of existing results. First, unobservable states concerning an unobservable BN are classified into three categories using the vertex-colored state transition graph, each accompanied by a necessary and sufficient condition for determining additional measurements to make them distinguishable. Then, an algorithm is designed to identify the additional measurements that would render an unobservable BN observable using the conditions. Next, to determine the minimum added measurements, a necessary and sufficient condition and an algorithm based on a constructed matrix are presented. Finally, the results obtained are compared with existing literature and illustrated with examples.
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http://dx.doi.org/10.1109/TCYB.2024.3464642 | DOI Listing |
J Chem Theory Comput
January 2025
Department of Chemistry, University of California, Berkeley, California 94720, United States.
Energy decomposition analysis (EDA) based on density functional theory (DFT) and self-consistent field (SCF) calculations has become widely used for understanding intermolecular interactions. This work reports a new approach to EDA for post-SCF wave functions based on closed-shell restricted second-order Mo̷ller-Plesset (MP2) together with an efficient implementation that generalizes the successful SCF-level second-generation absolutely localized molecular orbital EDA approach, ALMO-EDA-II, and improves upon MP2 ALMO-EDA-I. The new MP2 ALMO-EDA-II provides distinct energy contributions for a frozen interaction energy containing permanent electrostatics and Pauli repulsions, polarized energy-yielding induced electrostatics, dispersion-corrected energy, and the fully relaxed energy, which describes charge transfer.
View Article and Find Full Text PDFNatl J Maxillofac Surg
November 2024
Department of Prosthodontics, BBD CODS, Lucknow, Uttar Pradesh, India.
Introduction: Dental implants are the most popular alternative to rehabilitation of missing teeth and oro-facial structures. The outcome of such procedures depends on various factors and most-importantly on the osseo-integation with the surrounding bone. The evaluation needs better visualization and evaluation using CBCT anaylsis and determination of HU, using an appropriate software.
View Article and Find Full Text PDFDiabetes Ther
December 2024
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Introduction: ONWARDS 5 evaluated the effectiveness and safety of insulin icodec (icodec) titrated with a dosing guide app (icodec with app) versus once-daily insulin analogs in insulin-naive adults with type 2 diabetes. The insulin glargine U300 (glargine U300) stratum was too small to enable a robust post hoc efficacy comparison. Augmentation methodology was applied to increase the glargine U300 group size using real-world data (RWD), to facilitate efficacy comparisons of icodec with app versus glargine U300, and to demonstrate the potential of the augmentation methodology to strengthen underpowered treatment comparisons (AUGMENT study).
View Article and Find Full Text PDFPhys Med
January 2025
3DMI Research Group, Department of Medical Physics, School of Medicine, University of Patras, Rion, GR 26504, Greece; Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:
Injury
October 2024
Traumatology and Orthopaedics Surgery Department, Hospital Clínico Universitario Valladolid, Av. Ramón y Cajal, 47007, Valladolid, Spain; School of Medicine, Valladolid University, Av. Ramón y Cajal, 47007, Valladolid, Spain.
Introduction: The management of extracapsular proximal femoral fractures (EPFF) with intramedullary nails in the elderly is hindered by osteoporosis, leading to complications that significantly impact functionality due to restrictions for full weight-bearing. We hypothesized that cement augmentation of the cephalic blade could enhance the bone-implant interface and reduce mechanical failure, thereby improving patient functionality in the management of EPFF.
Materials And Methods: A retrospective cohort study was conducted on patients ≥ 70 years old with type 31-A EPFF (AO/OTA classification) treated with intramedullary nailing between 2017 and 2021, with and without cephalic blade augmentation with bone cement.
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