AI Article Synopsis
- Bronchopulmonary neuroendocrine neoplasms (BP-NENs) make up about 30% of all neuroendocrine neoplasms (NENs) and show similarities to gastroenteropancreatic NENs (GEP-NENs) but differ in classification.
- BP-NETs (previously known as carcinoids) are classified into typical (TC) and atypical carcinoids (AC), with the new WHO 2022 classification introducing NET G1 and G2 correspondingly.
- The review emphasizes the significance of the Ki-67 index for accurately classifying BP-NETs, noting that it is not included in their current classification criteria despite its relevance in
Article Abstract
Bronchopulmonary neuroendocrine neoplasms (BP-NENs) account for approximately 30% of all NENs. Although BP-NENs and NENs of the gastroenteropancreatic organs (GEP-NENs) share morphological and molecular features, they differ in terms of their terminology and classification. Bronchopulmonary neuroendocrine tumors (BP-NETs) have classically been termed as carcinoid and grouped into typical (TC) and atypical carcinoid (AC) based on the presence or absence of necrosis and mitotic count. In the most recent World Health Organization (WHO) classification for NENs of endocrine organs (WHO 2022), BP-NETs-NET G1 and G2-are introduced as synonyms of TC and AC, respectively. However, the Ki-67 index, which defines the grade of NETs in digestive organs, is only discussed in the descriptive text and not included into the criteria for classification of BP-NENs. In addition, well-differentiated NENs with high mitotic counts which correspond to NET G3 in the GEP organ system are not defined. This review discusses the role of Ki-67 for a proper classification of BP-NETs/carcinoids.
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| http://dx.doi.org/10.1007/s00292-024-01360-3 | DOI Listing |
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