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Software Integrated Personalized Biosensing Device for Serum Creatinine Detection Based on Boron doped MXene Nanohybrid. | LitMetric

Software Integrated Personalized Biosensing Device for Serum Creatinine Detection Based on Boron doped MXene Nanohybrid.

ACS Biomater Sci Eng

Laboratory of Bio-Physio Sensors and Nanobioengineering School of Biochemical Engineering, Indian Institute of Technology (BHU) Varanasi, Varanasi, Uttar Pradesh 221005, India.

Published: October 2024

AI Article Synopsis

  • The rise in chronic kidney disease (CKD) cases, especially in underdeveloped and developing countries, highlights the need for effective and accessible diagnostic tools.
  • A new immunosensor has been developed using advanced materials like gold nanoparticles and MXene to specifically detect creatinine levels in serum samples, demonstrating high sensitivity and a broad detection range.
  • The immunosensor is paired with a user-friendly software called "CretCheck," enabling easy analysis of creatinine levels, making it suitable for use in primary health care facilities.

Article Abstract

In recent years, an increase in the number of chronic kidney disease (CKD) cases has led to a global health burden majorly affecting underdeveloped and developing nations. A key biomarker for assessing the kidneys' normal functioning is creatinine, which is filtered out from the blood by the kidney. Thus, timely and specific detection of creatinine becomes necessary for diagnosis and subsequent treatment of CKD. Hence, in this study, we have tried to develop a field-deployable, software-integrated immunosensor for the detection of creatinine in a serum sample. The immunosensor was developed by incorporating gold nanoparticles, boron doped MXene, polyaniline, and anticreatinine antibody using an appropriate bioconjugation reaction. The developed sensor was able to detect creatinine in a linear dynamic range of 10 nM to 0.1 M with a limit of detection of 1.72 (±0.07) nM. The sensor was integrated with an indigenously developed software named "CretCheck" which simplifies the process of data analysis. The software integrated personalized biosensing device was used to find the creatinine concentrations directly from the obtained analytical signals. The developed immunosensor with the integrated software can also be implemented directly in primary health care facilities for creatinine detection in the future.

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Source
http://dx.doi.org/10.1021/acsbiomaterials.4c01451DOI Listing

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