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Lessons From COBALT: Will the Bell Also Toll for Thee?
Am J Gastroenterol
October 2024
Division of Gastroenterology/Hepatology, Scripps Clinic.
How to Build a Metalloenzyme: Lessons from a Protein-Based Model of Acetyl Coenzyme A Synthase.
Acc Chem Res
May 2023
Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
"What I cannot create, I do not understand"─Richard Feynman. This sentiment motivates the entire field of artificial metalloenzymes. Naturally occurring enzymes catalyze reactions with efficiencies, rates, and selectivity that generally cannot be achieved in synthetic systems.
View Article and Find Full Text PDFPattern of locoregional failure in postoperative cases of locally advanced carcinoma of buccal mucosa treated with unilateral versus bilateral neck radiation: lesson learned from a basic practice setup.
Rep Pract Oncol Radiother
December 2022
Department of Radiotherapy, Medical College Kolkata, India.
Article Synopsis
- Carcinoma of buccal mucosa is a common oral cancer in India, and this study investigates whether unilateral or bilateral neck irradiation improves locoregional control in patients with well-lateralized cancers without involved nodes in the contralateral neck.
- The study involved 48 patients, divided into unilateral and bilateral radiation treatment groups; results showed no significant difference in disease recurrence between the two groups after a median follow-up of 23 months.
- Findings indicate that bilateral neck radiation does not have advantages over unilateral irradiation for selected patients, highlighting that it may lead to increased radiation exposure to healthy tissues without improving disease-free survival rates.
Lessons learned from independent external validation of an AI tool to detect breast cancer using a representative UK data set.
Br J Radiol
March 2023
Royal Surrey NHS Foundation Trust, Guildford, United Kingdom.
Objective: To pilot a process for the independent external validation of an artificial intelligence (AI) tool to detect breast cancer using data from the NHS breast screening programme (NHSBSP).
Methods: A representative data set of mammography images from 26,000 women attending 2 NHS screening centres, and an enriched data set of 2054 positive cases were used from the OPTIMAM image database. The use case of the AI tool was the replacement of the first or second human reader.
Treatment of life-threatening H2S intoxication: Lessons from the trapping agent tetranitrocobinamide.
Environ Toxicol Pharmacol
November 2022
Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
We sought to evaluate the efficacy of trapping free hydrogen sulfide (HS) following severe HS intoxication. Sodium hydrosulfide solution (NaHS, 20 mg/kg) was administered intraperitoneally in 69 freely moving rats. In a first group (protocol 1), 40 rats were randomly assigned to receive saline (n = 20) or the cobalt compound tetranitrocobinamide (TNCbi) (n = 20, 75 mg/kg iv), one minute into coma, when free HS was still present in the blood.
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