The neurotransmitter dopamine helps form long-term memories by increasing the production of proteins through a unique signaling pathway.
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| http://dx.doi.org/10.7554/eLife.102837 | DOI Listing |
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Multidimensional Classification and Prediction of Outcome Following Traumatic Brain Injury.
J Head Trauma Rehabil
January 2025
Author Affiliations: Monash-Epworth Rehabilitation Research Centre, School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia (Prof Ponsford and Drs Spitz, Pyman, Carrier, Hicks, and Nguyen); Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia (Dr Spitz); TIRR Memorial Hermann Research Center Houston, Texas (Drs Sander and Sherer); and H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine & Harris Health System, Houston, Texas (Drs Sander and Sherer).
Objectives: This study aimed to identify outcome clusters among individuals with traumatic brain injury (TBI), 6 months to 10 years post-injury, in an Australian rehabilitation sample, and determine whether scores on 12 dimensions, combined with demographic and injury severity variables, could predict outcome cluster membership 1 to 3 years post-injury.
Setting: Rehabilitation hospital.
Participants: A total of 467 individuals with TBI, aged 17 to 87 (M = 44.
Volatile Resistive Switching and Short-Term Synaptic Plasticity in a Ferroelectric-Modulated SrFeO Memristor.
ACS Appl Mater Interfaces
January 2025
Institute for Advanced Materials and Guangdong Provincial Key Laboratory of Optical Information Materials and Technology, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China.
SrFeO (SFO) offers a topotactic phase transformation between an insulating brownmillerite SrFeO (BM-SFO) phase and a conductive perovskite SrFeO (PV-SFO) phase, making it a competitive candidate for use in resistive memory and neuromorphic computing. However, most of existing SFO-based memristors are nonvolatile devices which struggle to achieve short-term synaptic plasticity (STP). To address this issue and realize STP, we propose to leverage ferroelectric polarization to effectively draw ions across the interface so that the PV-SFO conductive filaments (CFs) can be ruptured in absence of an external field.
View Article and Find Full Text PDFEvaluation of machine learning techniques for real-time prediction of implanted lower limb mechanics.
Front Bioeng Biotechnol
January 2025
Center for Orthopaedic Biomechanics, University of Denver, Denver, CO, United States.
Introduction: Accurate prediction of knee biomechanics during total knee replacement (TKR) surgery is crucial for optimal outcomes. This study investigates the application of machine learning (ML) techniques for real-time prediction of knee joint mechanics.
Methods: A validated finite element (FE) model of the lower limb was used to generate a dataset of knee joint kinematics, kinetics, and contact mechanics.
The mind, brain, and body study: A protocol for examining the effects of the gut-brain-immune axis on internalizing symptoms in youth exposed to caregiving-related early adversity.
Brain Behav Immun Health
December 2024
Department of Psychology, University of California, Los Angeles, 502 Portola Plaza, Los Angeles, CA, 90095, USA.
Experiences of caregiving-related adversity are common and one of the strongest predictors of internalizing psychopathology (i.e., anxiety and depression).
View Article and Find Full Text PDFMemScreen: A smartphone application for detection of mild cognitive impairment: A validation study: Smartphone App for MCI Detection.
J Prev Alzheimers Dis
January 2025
Université Paris Cité, INSERM U1153, Centre of Research in Epidemiology and Statistics, Team Epidemiology of Ageing and Neurodegenerative Diseases, 10 avenue de Verdun, 75010 Paris, France; Faculty of Brain Sciences, University College London, 38-50 Bidborough Street, WC1H 9BT London, UK.
Background And Objectives: Primary care is often the first point of contact for patients with cognitive complaints, making initial cognitive screening an essential step to avoid delays in diagnosing Alzheimer's disease (AD) at an early stage. We developed MemScreen, a self-administered smartphone application that assesses overall cognition and verbal memory, and evaluated its ability to detect mild cognitive impairment (MCI) in both general and clinical populations.
Methods: We conducted two validation cohort studies: (1) UK-based Whitehall II cohort study (13th wave, 2018-2022) involving a general population (MCI defined by poor performance on a global cognitive score), and (2) five French memory clinics involving patients without dementia (amnestic MCI defined by the Free and Cued Selective Reminding Test).
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