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Biopsy location and tumor-associated macrophages in predicting malignant glioma recurrence using an in-silico model.
NPJ Syst Biol Appl
January 2025
Center for Interdisciplinary Digital Sciences (CIDS), Department Information Services and High-Performance Computing (ZIH), Dresden University of Technology, 01062, Dresden, Germany.
Predicting the biological behavior and time to recurrence (TTR) of high-grade diffuse gliomas (HGG) after maximum safe neurosurgical resection and combined radiation and chemotherapy plays a pivotal role in planning clinical follow-up, selecting potentially necessary second-line treatment and improving the quality of life for patients diagnosed with a malignant brain tumor. The current standard-of-care (SoC) for HGG includes follow-up neuroradiological imaging to detect recurrence as early as possible and relies on several clinical, neuropathological, and radiological prognostic factors, which have limited accuracy in predicting TTR. In this study, using an in-silico analysis, we aim to improve predictive power for TTR by considering the role of (i) prognostically relevant information available through diagnostics used in the current SoC, (ii) advanced image-based information not currently part of the standard diagnostic workup, such as tumor-normal tissue interface (edge) features and quantitative data specific to biopsy positions within the tumor, and (iii) information on tumor-associated macrophages.
View Article and Find Full Text PDFDon't Sleep on Sleep: A Case Report from a Division I Heptathlete.
J Athl Train
December 2024
Musculoskeletal Adaptations to Aging and eXercise (MAAX) Laboratory, Oklahoma State University, Stillwater, OK, USA.
A female NCAA Division I track athlete experienced non-localized shin pain midway through her first season, which was diagnosed as medial tibial stress syndrome. Treatments included strengthening and range of motion exercises, reduced training volume, and pain control modalities, but symptoms worsened. It was revealed she had been suffering from severe sleep deprivation (<3 hours/night) contributing to bilateral tibial and fibular stress reactions.
View Article and Find Full Text PDFAssociation between soy products and prostate cancer: A systematic review and meta-analysis of observational studies.
Investig Clin Urol
November 2024
Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Purpose: The effect of soy products on prostate cancer (PCA) remains a topic of debate. This study aimed to investigate the association between soy products consumption and the incidence of PCA.
Materials And Methods: A search was conducted in the PubMed, EBSCO, Web of Science, and Cochrane Library databases up to December 2023.
Complication avoidance, rehabilitation, pain therapy and palliative care for patients with metastatic spine tumors: WFNS spine committee recommendations.
Neurosurg Rev
October 2024
Department of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
Objective: This review aims to formulate the most current, evidence-based recommendations regarding complication avoidance, rehabilitation, pain therapy and palliative care for patients with metastatic spine tumors.
Methods: A systematic literature search in PubMed and MEDLINE, and was performed from 2013 to 2023 using the search terms "complications" + "spine metastases", "spine metastases" + + "rehabilitation", "spine metastases" + "pain therapy" + "palliative care". Screening criteria resulted in 35, 15 and 56 studies respectively that were analyzed.
Early and late outcomes of video thoracoscopic versus open approach for bronchiectasis lung resections.
Rev Col Bras Cir
September 2024
- Universidade de Sao Paulo (HCFMUSP), Cirurgia Torácica - São Paulo - SP - Brasil.
Objectives: To evaluate the early and late results of surgical treatment of patients with bronchiectasis, comparing the Video-Assisted Thoracic Surgery (VATS) vs. the open thoracotomy (OT).
Methods: Observational retrospective study of patients who underwent surgery for bronchiectasis.
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