PSMA-targeted radiopharmaceutical therapy is an established treatment option for metastatic castration-resistant prostate cancer (mCRPC). However, response rates and duration using Lu-PSMA-617 vary considerably between patients. Quantitative Lu SPECT imaging is one approach that may be leveraged to more closely monitor inter-cycle response, as well as patient-specific absorbed doses. In this work, we describe our experience implementing quantitative imaging throughout the course of Lu-PSMA treatment, including serial SPECT imaging to monitor response and for individualized dosimetry. We also describe our imaging protocols and dose calculation workflows for 3D voxelized patient-specific organ and tumor dosimetry, including a review of the current landscape and efforts towards harmonized dosimetry.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440845 | PMC |
| http://dx.doi.org/10.3389/fnume.2023.1291253 | DOI Listing |
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