AI Article Synopsis
- The study investigates how different areas of the hippocampus use sleep oscillations during NREM sleep to aid memory consolidation, particularly focusing on delta waves and spindle activity.
- Using data from 25 epilepsy patients with intracranial recordings, it reveals that various hippocampal subfields (DG/CA3, CA1, and SUB) display significant delta and spindle power during NREM sleep and that these areas interact in complex ways.
- The findings indicate that while the DG/CA3 region shows strong coupling between different oscillations, CA1 and SUB demonstrate more precise coordination, ultimately enhancing synaptic plasticity and information transfer during sleep.
Article Abstract
The integration of hippocampal oscillations during non-rapid eye movement (NREM) sleep is crucial for memory consolidation. However, how cardinal sleep oscillations bind across various subfields of the human hippocampus to promote information transfer and synaptic plasticity remains unclear. Using human intracranial recordings from 25 epilepsy patients, we find that hippocampal subfields, including DG/CA3, CA1, and SUB, all exhibit significant delta and spindle power during NREM sleep. The DG/CA3 displays strong coupling between delta and ripple oscillations with all the other hippocampal subfields. In contrast, the regions of CA1 and SUB exhibit more precise coordination, characterized by event-level triple coupling between delta, spindle, and ripple oscillations. Furthermore, we demonstrate that the synaptic plasticity within the hippocampal circuit, as indexed by delta-wave slope, is linearly modulated by spindle power. In contrast, ripples act as a binary switch that triggers a sudden increase in delta-wave slope. Overall, these results suggest that different subfields of the hippocampus regulate one another through diverse layers of sleep oscillation synchronization, collectively facilitating information processing and synaptic plasticity during NREM sleep.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445409 | PMC |
| http://dx.doi.org/10.1038/s42003-024-06941-9 | DOI Listing |
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