AI Article Synopsis
- The seventh cholera pandemic started in 1961 in Indonesia and spread worldwide in three waves.
- Scientists studied the basic building blocks (genomes) of bacteria from 1961 to 1979 to understand how it spread.
- They found that specific changes in the bacteria helped it spread more easily, and this research can help us stop cholera in the future.
Article Abstract
The seventh cholera pandemic started in 1961 in Indonesia and spread across the world in three waves in the decades that followed. Here, we utilised genomic evidence to detail the first wave of the seventh pandemic. Genomes of 22 seventh pandemic Vibrio cholerae isolates from 1961 to 1979 were completely sequenced. Together with 152 publicly available genomes from the same period, they fell into seven phylogenetic clusters (CL1-CL7). By multilevel genome typing (MGT), all were assigned to MGT2 ST1 (Wave 1) except three isolates in CL7 which were typed as MGT2 ST2 (Wave 2). The Wave 1 seventh pandemic expanded in two stages, with Stage 1 (CL1-CL5) spread across Asia and Stage 2 (CL6 and CL7) spread to the Middle East and Africa. Three non-synonymous mutations, one each, in three regulatory genes, csrD (global regulator), acfB (chemotaxis), and luxO (quorum sensing) may have critically contributed to its pandemicity. The three MGT2 ST2 isolates in CL7 were the progenitors of Wave 2 and evolved from within Wave 1 with acquisition of a novel IncA/C plasmid. Our findings provide new insight into the evolution and transmission of the early seventh pandemic, which may aid future cholera prevention and control.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445481 | PMC |
| http://dx.doi.org/10.1038/s41467-024-52800-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Relationship between burnout and turnover intention among nurses: a network analysis.
BMC Nurs
December 2024
Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Background: Nurse burnout and turnover intention significantly impact global healthcare systems, especially intensified by the COVID-19 pandemic. This study employs network analysis to explore these phenomena, providing insights into the interdependencies and potential intervention points within the constructs of burnout and turnover intention among nurses.
Methods: A cross-sectional study was conducted with 560 nurses from three tertiary hospitals in Hangzhou, China.
A novel genomic island encodes vibrioferrin synthesis in the marine pathogen Photobacterium damselae subsp. damselae.
Microb Pathog
December 2024
Department of Microbiology and Parasitology, Aquatic One Health Research Center (ARCUS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain. Electronic address:
Article Synopsis
- The study discovered a new genomic island (pddGI-1) in the marine pathogen Photobacterium damselae, located on chromosome II.
- This genomic island shares features with other islands in Vibrio species and consists of genes for antioxidant defense, energy metabolism, and systems that modify DNA.
- The pddGI-1 also includes a complete system for vibroferrin, which helps the bacteria thrive in low-iron environments, suggesting that strains with this island have a growth advantage in such conditions.
Inequality in pandemic effects on school track placement and the role of social and academic embeddedness.
NPJ Sci Learn
November 2024
Maastricht University, the Netherlands, Netherlands Initiative for Education Research (NRO), and NOLAI, Radboud University, Nijmegen, the Netherlands.
Using register data and linked student-level sociometric survey data from the Netherlands, this study examines whether the impact of the COVID-19 pandemic on schooling outcomes (track recommendation and track enrollment in the seventh and ninth grades) is conditional on students' academic and social embeddedness in the school setting. We estimated the counterfactual outcomes for the cohort that went through the school transition during the pandemic based on the outcomes of the pre-pandemic cohort, with similar earlier achievements, schools, and social backgrounds. Results show that the pandemic's effect on tracking outcomes is weaker than its effect on student test scores elsewhere reported.
View Article and Find Full Text PDFMaternal infection of SARS-CoV-2 during the first and second trimesters leads to newborn telomere shortening.
J Transl Med
November 2024
Department of Medicine, Division of Hematology, Bioclinicum, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
Article Synopsis
- Research shows that the initial telomere length in newborns is critical for their long-term health, and potential effects of maternal SARS-CoV-2 infection on prenatal telomere homeostasis are being studied.
- In a study of 413 newborns, those born to mothers infected with SARS-CoV-2 during the first and second trimesters had significantly shorter telomeres compared to those from non-infected mothers, highlighting the timing of infection's impact.
- The results indicate that early maternal infection is correlated with worse fetal telomere health, alongside signs of placental aging and decreased expression of telomerase, but no significant cytokine level differences were noted between the
Prevalence and influencing factors of PTSD symptoms among the general population during the surge period of COVID-19 pandemic in mainland China.
Gen Hosp Psychiatry
October 2023
School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address:
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!