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SNX3 mediates heart failure by interacting with HMGB1 and subsequently facilitating its nuclear-cytoplasmic translocation.
Acta Pharmacol Sin
January 2025
National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Sorting nexins (SNXs) as the key regulators of sorting cargo proteins are involved in diverse diseases. SNXs can form the specific reverse vesicle transport complex (SNXs-retromer) with vacuolar protein sortings (VPSs) to sort and modulate recovery and degradation of cargo proteins. Our previous study has shown that SNX3-retromer promotes both STAT3 activation and nuclear translocation in cardiomyocytes, suggesting that SNX3 might be a critical regulator in the heart.
View Article and Find Full Text PDFClinical trials in neuromodulatory treatment of drug-resistant hypertension and the need for spinal cord stimulation trials: a PRISMA systematic review.
Bioelectron Med
December 2024
Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Background: Drug-resistant hypertension affects approximately 9-18% of the United States hypertensive population. Recognized as hypertension that is resistant to three or more medications, drug-resistant hypertension can lead to fatal sequelae, such as heart failure, aortic dissection, and other vast systemic disease. The disruption of the homeostatic mechanisms that stabilize blood pressure can be treated procedurally when medication fails.
View Article and Find Full Text PDFSorting out aortic aneurysms: A team enterprise.
Cleve Clin J Med
October 2024
Professor Emeritus, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; Retired Chair, Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH
Role of CD34 in calcification of human aortic valve interstitial cells from patients with aortic valve stenosis.
J Pharmacol Sci
November 2024
Department of Vascular and Inflammatory Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan. Electronic address:
Article Synopsis
- The study investigates the role of CD34 in human aortic valve interstitial cells (HAVICs) related to calcified aortic valve stenosis (CAVS), highlighting the complexity of calcification factors involved.
- It was found that CD34-negative HAVICs are more sensitive to calcification stimuli and that the expression of tenascin X (TNX) mRNA significantly decreases in these cells.
- The research suggests that CD34 acts as an inhibitory regulator against valve calcification, particularly by counteracting the effects of inflammatory cytokines like TNF-α and IL-1β, which lower CD34 expression and contribute to increased calcification.
The heart is a resident tissue for hematopoietic stem and progenitor cells in zebrafish.
Nat Commun
August 2024
Institute of Cell Biology, Faculty of Medicine, University of Münster, Münster, 48149, Germany.
The contribution of endocardial cells (EdCs) to the hematopoietic lineages has been strongly debated. Here, we provide evidence that in zebrafish, the endocardium gives rise to and maintains a stable population of hematopoietic cells. Using single-cell sequencing, we identify an endocardial subpopulation expressing enriched levels of hematopoietic-promoting genes.
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