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Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment.
Heliyon
December 2024
Department of Radiation Biology & Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, India.
Despite years of development in cancer therapy, achieving successful cancer treatment remains a major research topic. Primary means of cancer treatment include chemotherapy, radiotherapy, and surgery. However, these modalities are associated with limitations and adverse effects on normal tissues.
View Article and Find Full Text PDFEnhanced targeting efficacy of baicalein analogues on the dimeric state of SARS-CoV-2 3CL protease compared to monomeric state.
J Biomol Struct Dyn
December 2024
Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
The COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2, has been a global threat affecting the entire world. It is a single-stranded RNA virus that belongs to the coronavirus family. In SARS-CoV2, the 3CL protease protein significantly contributes to viral replication and is responsible for viral polyprotein cleavage.
View Article and Find Full Text PDFHomoplantaginin Antagonizes -Methyl-d-aspartate Receptor and Extracellular Signal-Regulated Kinase Signaling in Aβ Oligomers-Induced Neuropathology/Toxicity.
J Agric Food Chem
December 2024
Department of Life Science, National Taiwan Normal University, Taipei 116325, Taiwan.
Extracts from plants/herbals are great resources of drugs and nutrients. Baicalein, a component present in , was previously found to alleviate the abnormal depolarization brought about by Aβ oligomers. We extended this promising outcome by screening baicalein derivatives, and a natural compound named homoplantaginin was pinpointed.
View Article and Find Full Text PDFIntegrative Metabolomic and Transcriptomic Analysis Provides Novel Insights into the Effects of SO on the Postharvest Quality of 'Munage' Table Grapes.
Foods
October 2024
Guangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables, Engineering Research Center of Southern Horticultural Products Preservation, Ministry of Education, College of Horticulture, South China Agricultural University, Guangzhou 510642, China.
Postharvest grapes exhibit a limited shelf life due to susceptibility to rot and deterioration, significantly reducing their nutritional and economic value. Sulfur dioxide (SO) is a widely recognized preservative for extending grape storage life. This study performed a detailed analysis of 'Munage' table grapes treated with SO fumigation, employing transcriptomic and metabolomic approaches.
View Article and Find Full Text PDFPromotion of a quality standard for Scutellariae radix based on the anti-inflammatory efficacy-oriented quality marker of the effect-constituent index.
Anal Methods
December 2024
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, P.R.China.
Article Synopsis
- - The quality control of herbal medicines is crucial for ensuring their effectiveness in clinical use, but current quality evaluation methods often overlook the link between chemical properties and clinical efficacy.
- - This study introduces a new quality standard system, the efficacy-oriented Q-marker of the effect-constituent index (ECI), focusing on Scutellariae Radix (SR), a popular herbal medicine known for its various therapeutic properties.
- - By analyzing key markers associated with anti-inflammatory effects, the study demonstrates that the ECI can effectively correlate with and predict the therapeutic quality of SR, offering insights that could improve quality evaluation for other herbal medicines.
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