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Failure to replicate University of Chicago Press, 2024. 416 pp.
Science
January 2025
The reviewer is at the Department of the History of Science, Harvard University, Cambridge, MA, USA.
A historian confronts the complicated origins and uncertain future of priming research.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Alzheimer Center Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Background: Recent advancements in Alzheimer's disease (AD) biomarker research and AD drug trials prompt reflection on the value and appropriate use of tau-PET in future clinical practice and trials. We therefore conducted a survey among dementia and PET experts worldwide to investigate how they envision the future role of tau-PET in clinical practice and trials.
Method: An online survey was distributed to dementia clinicians and researchers who were invited to participate through personalized emails, social media channels and/or presentations at relevant conferences.
Developing Topics.
Alzheimers Dement
December 2024
Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Executive dysfunction is a hallmark clinical feature of frontotemporal degeneration (FTD). Genome-wide association studies have identified genetic variants, and resulting polygenic scores (PGS), related to executive function (EF) in population studies. We evaluated whether EF-PGS correlates with differential rates of cognitive decline in FTD.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Pennsylvania, Philadelphia, PA, USA.
Background: People living with Alzheimer's disease and related dementias confront numerous decisions that affect their wellbeing, as well as that of their family members. Research demonstrates the importance of family involvement in such decision making, yet there is a lack of knowledge about how patients and families work together to make decisions and how families can best provide decisional support.
Methods: Semi-structured interviews were conducted separately with 15 patients diagnosed with mild cognitive impairment (MCI) or mild dementia, identified through a National Institute on Aging-funded Alzheimer's Disease Research Center, and 14 care partners.
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.
Background: Due to further development of diagnostic methods of early-stage diagnosis of Alzheimer's disease (AD) and new disease-modifying treatment options that require early diagnosis, a new focus on predictive and preventive medicine arises. With progress in AD dementia risk estimation, guidelines for counseling, considering individual aspects of those affected, are becoming more important. As part of the trinational project PreTAD (The Predictive Turn in Alzheimer's Disease: Ethical, Clinical, Linguistic and Legal Aspects) anticipated effects of AD dementia risk estimation for first-degree relatives of people with AD dementia are evaluated.
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