AI Article Synopsis

  • A new extraction method called NADES-UAE (natural deep eutectic solvent-based ultrasound-assisted extraction) was developed to extract camptothecin (CPT) and 10-hydroxycamptothecin (10-HCPT) from fruit powder.
  • This method achieved high yields of 1.31 mg of CPT and 1.66 mg of 10-HCPT per gram of fruit, using optimal conditions such as 20% water content and a 20-minute ultrasound time.
  • The research showed that the NADES3 solvent not only improved extraction efficiency compared to traditional solvents but could also be reused multiple times, making it a sustainable and eco-friendly option for extraction processes.

Article Abstract

A natural deep eutectic solvent-based ultrasound-assisted simultaneous extraction (NADES-UAE) of camptothecin (CPT) and 10-hydroxycamptothecin (10-HCPT) was established. The 1.31 mg of CPT and 1.66 mg of 10-HCPT were obtained from each gram of the fruit powder of under the optimum conditions with a water content of 20%, a liquid-solid ratio of 12 mL/g and an ultrasound time of 20 min. The recovery efficiencies of CPT and 10-HCPT after AB-8 resin enrichment were 70.5% and 74.8%, respectively. The stronger interaction between NADES3 which was screened from 12 kinds of NADES and target components compared with methanol or water was demonstrated using molecular dynamics simulation. Moreover, the recovered NADES3 could be reused at least 4 times. The present research provided an efficient, environment-friendly, and sustainable method for extracting and recovering CPT and 10-HCPT from the fruits of .

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http://dx.doi.org/10.1080/14786419.2024.2411363DOI Listing

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