AI Article Synopsis
- Obesity is linked to chronic diseases and certain cancers, and this study highlights the role of circadian genes in its progression, shedding light on the immune systems of obese patients.
- The researchers used machine learning and Mendelian randomization to identify three significant circadian genes (BHLHE40, PPP1CB, and CSNK1E) impacting obesity and explored their interactions with immune cells.
- These findings suggest that these circadian genes could be new biomarkers and therapeutic targets for obesity management and treatment.
Article Abstract
Objective: Obesity, a global health concern, is associated with a spectrum of chronic diseases and cancers. Our research sheds light on the regulatory role of circadian genes in obesity progression, providing insight into the immune landscape of obese patients, and introducing new avenues for therapeutic interventions.
Methods: Expression files of multiple datasets were retrieved from the GEO database. By 80 machine-learning algorithm combinations and Mendelian randomization analysis, we discovered the key circadian genes contributing to and protecting against obesity. Subsequently, an immune infiltration analysis was conducted to examine the alterations in immune cell types and their abundance in the body and to investigate the relationships between circadian genes and immune cells. Furthermore, we delved into the molecular mechanisms of key genes implicated in obesity.
Results: Our study identified three key circadian genes (BHLHE40, PPP1CB, and CSNK1E) associated with obesity. BHLHE40 was found to promote obesity through various pathways, while PPP1CB and CSNK1E counteracted lipid metabolism disorders, and modulated cytokines, immune receptors, T cells, and monocytes.
Conclusion: In conclusion, the key circadian genes (BHLHE40, CSNK1E, and PPP1CB) may serve as novel biomarkers for understanding obesity pathogenesis and have significant correlations with infiltrating immune cells, thus providing potential new targets for obese prevention and treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439728 | PMC |
| http://dx.doi.org/10.3389/fnut.2024.1407265 | DOI Listing |
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