: Unraveling its potential role in gastric carcinogenesis.

World J Gastroenterol

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg 39120, Germany.

Published: September 2024

AI Article Synopsis

  • () is a Gram-negative anaerobic bacterium linked to oral diseases like periodontitis and gingivitis, as well as colorectal cancer development and progression.
  • Its role in gastric cancer is not well understood, despite it being a significant risk factor for the disease.
  • The review highlights current knowledge on ()’s involvement in gastric carcinogenesis and discusses its potential clinical implications.

Article Abstract

() is a Gram-negative anaerobic bacterium that plays a key role in the development of oral inflammation, such as periodontitis and gingivitis. In the last 10 years, has been identified as a prevalent bacterium associated with colorectal adenocarcinoma and has also been linked to cancer progression, metastasis and poor disease outcome. While the role of in colon carcinogenesis has been intensively studied, its role in gastric carcinogenesis is still poorly understood. Although infection has historically been recognized as the strongest risk factor for the development of gastric cancer (GC), with recent advances in DNA sequencing technology, other members of the gastric microbial community, and in particular, have received increasing attention. In this review, we summarize the existing knowledge on the involvement of in gastric carcinogenesis and address the potential translational and clinical significance of in GC.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438658PMC
http://dx.doi.org/10.3748/wjg.v30.i35.3972DOI Listing

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