AI Article Synopsis

  • Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome, is a serious condition causing inflammation in blood vessels, mainly affecting the respiratory system.
  • A study on seven patients at Cleveland Clinic Abu Dhabi examined the effects of mepolizumab, looking at factors such as vasculitis activity and asthma symptoms before and after treatment.
  • Results showed significant improvements, including reduced disease activity and lower doses of prednisolone, indicating that mepolizumab is a safe and effective option for treating EGPA.

Article Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss syndrome, is a systemic vasculitis characterized by eosinophil-rich, necrotizing granulomatous inflammation primarily affecting the respiratory tract with necrotizing vasculitis of small- to medium-sized arteries. In this case series, we retrospectively evaluated the efficacy and safety of mepolizumab in seven patients diagnosed with EGPA who presented to the Department of Allergy and Clinical Immunology at Cleveland Clinic Abu Dhabi. The variables assessed before and after mepolizumab treatment included Birmingham Vasculitis Activity Score (BVAS), prednisolone dose, Asthma Control Test (ACT) score, and blood eosinophil count (BEC). We found a significant reduction in BVAS and prednisolone dosage with clinical improvements in asthma symptoms after treatment with mepolizumab. Our case series, the first from the Middle East on the use of mepolizumab in EGPA, demonstrates that mepolizumab is a safe and effective treatment for patients with EGPA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440447PMC
http://dx.doi.org/10.7759/cureus.68282DOI Listing

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