Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jmv.29949 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tracking astrocyte polarization in the retina in retinopathy of prematurity.
Exp Eye Res
January 2025
Department of Ophthalmology, Affiliated Hospital of Yunnan University, The Second People's Hospital of Yunnan Province, No.176, Qingnian Road, Kunming, Yunnan, 650000, China. Electronic address:
Article Synopsis
- Astrocyte patterns play a significant role in the development of the retinal vascular network in retinopathy of prematurity (ROP), with their interaction involving VEGF secretion being a key focus of the study.
- Research used an oxygen-induced retinopathy (OIR) mouse model to explore changes in reactive astrocytes (A1 and A2) and their correlation with VEGF levels at various developmental stages.
- Findings revealed that while A1 reactive astrocytes increased initially and then normalized, A2 reactive astrocytes only peaked later, indicating that astrocyte activity and VEGF expression exhibit opposite trends during critical periods of vasculature changes.
Edaravone Dexborneol provides neuroprotective effect by inhibiting neurotoxic activation of astrocytes through inhibiting NF-κB signaling in cortical ischemia.
Brain Res Bull
November 2024
Department of Neurology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China. Electronic address:
Article Synopsis
- Edaravone Dexborneol (EDB) is a combination treatment shown to have antioxidant and anti-inflammatory effects that may protect against stroke.
- The study investigates how EDB can reduce neuronal death by altering the harmful activation of A1 astrocytes after cerebral ischemia.
- Results indicate that EDB not only improves behavioral outcomes and neuronal survival in mice but also suppresses neurotoxic A1 astrocyte activation through the inhibition of the NF-κB signaling pathway.
Activation of chaperone-mediated autophagy exerting neuroprotection effect on intracerebral hemorrhage-induced neuronal injury by targeting Lamp2a.
Exp Neurol
December 2024
Department of Geriatrics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, Jiangsu Province, China. Electronic address:
Article Synopsis
- Intracerebral hemorrhage (ICH) is a type of stroke that causes serious brain damage and makes people very sick.
- This study looks at how certain brain cells called astrocytes react after ICH and how they can cause more brain injury.
- Researchers found that a particular protein, Lamp2a, helps protect brain cells after ICH, and activating it could help improve recovery from this type of stroke.
A1-reactive astrocytes and IFNAR signaling collectively induce neuronal cell death during infection of IFNAR1-/- mice by severe fever with thrombocytopenia syndrome virus.
J Med Virol
October 2024
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, Minnesota, USA.
Botch improves cognitive impairment after cerebral ischemia associated with microglia-induced A1-type astrocyte activation.
Neurobiol Dis
October 2024
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, Jiangsu Province, China; Institute of Stroke Research, Soochow University, 188 Shizi Street, Suzhou 215006, Jiangsu Province, China. Electronic address:
Article Synopsis
- Vascular cognitive impairment (VCI) is a significant type of dementia caused by cerebrovascular problems and currently has no effective treatments.
- The study investigates Botch, a natural inhibitor of the Notch1 pathway, in a rat model of VCI and finds that its down-regulation leads to increased neuroinflammation and cognitive decline.
- Re-expressing Botch helps reduce inflammation, protect neurons, and improve cognitive function, suggesting it could be a promising target for developing VCI treatments.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!