AI Article Synopsis
- Melanogenesis is the process of melanin production, essential for skin pigmentation, and its dysregulation can lead to issues like hyperpigmentation disorders.
- A new extract, (1'S, 2'S)-syringyl glycerol 3'-O-β-D-glucopyranoside (compound 5), showed significant anti-melanogenic effects, reducing melanin synthesis by about 36% and tyrosinase activity by over 48%.
- The study suggests that compound 5 influences key signaling pathways related to melanin production, making it a viable option for treating hyperpigmentation issues.
Article Abstract
Introduction: Melanogenesis, the process responsible for melanin production, is a critical determinant of skin pigmentation. Dysregulation of this process can lead to hyperpigmentation disorders.
Method: In this study, we identified a novel extract, (1'S, 2'S)-syringyl glycerol 3'-O-β-D-glucopyranoside (compound 5), and evaluated its anti-melanogenic potential in zebrafish models and assays. Compound 5 inhibited melanin synthesis by 36.66% ± 14.00% and tyrosinase by 48.26% ± 6.94%, surpassing the inhibitory effects of arbutin. Network pharmacological analysis revealed key targets, including HSP90AA1, HRAS, and PIK3R1, potentially involved in the anti-melanogenic effects of compound 5.
Results: Molecular docking studies supported the interactions between compound 5 and these targets. Further, gene expression analysis in zebrafish indicated that compound 5 up-regulates and and subsequently down-regulating tyr, and tyrp1, critical genes in melanogenesis.
Conclusion: These findings suggest that compound 5 inhibits melanin production PI3K-Akt and Ras-Raf-MEK-ERK signaling pathways, positioning it as a promising candidate for the treatment of hyperpigmentation.
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| http://dx.doi.org/10.2174/0109298673341645240919072455 | DOI Listing |
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