AI Article Synopsis
- SNP-based association studies have changed the biomedical landscape, focusing on the genetic factors influencing susceptibility to enteric fever, which is caused by Salmonella enterica serovar typhi and paratyphi.
- A study in the Punjabi population examined the PARK2_e01(-697) polymorphism to see if it was linked to an increased risk of typhoid fever using blood samples from patients and healthy controls.
- The results showed no significant association between the PARK2_e01(-697) polymorphism and susceptibility to typhoid fever, suggesting that further research with larger sample sizes is needed to better understand its potential role in the disease.
Article Abstract
Background: SNP based association studies have revolutionized the field of biomed-icines. Enteric fever is a systemic disease with etiologic agents Salmonella enterica serovar typhi and paratyphi. It is a serious health issue worldwide and presents wide variations in incidence, rates, and severity. Previous investigations have revealed that genetic variations may lead to sus-ceptibility to typhoid fever. A current study was performed to investigate the potential association of PARK2_e01(-697) polymorphism with the susceptibility to typhoid in the Punjabi population.
Methods: For this case-control study, blood samples obtained from typhoid patients with positive Typhidot or blood culture test (n=72) and healthy controls (n=73) were processed for DNA ex-traction. The polymorphism PARK2_e01(-697) analysis was carried out by using PCR and RFLP.
Results: No allelic association was found between PARK2_e01(-697) and susceptibility to ty-phoid fever in the understudy population.
Conclusion: This case control study is the demonstration of the non-association of PARK2_e01(-697) with typhoid in the Pakistani population. Future research, using a larger population size, will help to elucidate the role of PARK2_e01(-697) polymorphism in typhoid pathogenesis.
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| http://dx.doi.org/10.2174/0118715265305304240918063848 | DOI Listing |
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