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Systemic lupus erythematosus: one year in review 2025.
Clin Exp Rheumatol
March 2025
Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
This review highlights key advancements in systemic lupus erythematosus (SLE) research during 2024, covering pathogenesis, novel therapies, biomarkers, and clinical outcomes. Notable findings include new insights into immune dysregulation, promising therapeutic targets, and real-world data confirming the efficacy of anifrolumab and belimumab. Advances in biomarkers enhance disease monitoring, while multidisciplinary approaches improve reproductive outcomes and quality of life.
View Article and Find Full Text PDF[Association of systemic lupus and HIV/AIDS: nine observations at the Centre Hospitalier Universitaire de Libreville (Gabon)].
Med Trop Sante Int
December 2024
Service de médecine interne, CHU de Libreville, BP 2228, Libreville, Gabon.
Background: HIV/AIDS infection is endemic in sub-Saharan Africa. It is manifested by a variety of opportunistic diseases that usually occur when the CD4 count is below 200/mm, but also during the immune restoration syndrome (IRS) that occurs under highly active antiretroviral therapy (HAART). Autoimmune and inflammatory diseases are rarely associated with this condition.
View Article and Find Full Text PDFIntracranial vessel wall enhancement scoring system for monitoring disease activity and neuropsychiatric impairment in systemic lupus erythematosus.
Eur J Radiol
March 2025
Department of Radiology, The Second Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, China. Electronic address:
Objectives: To establish an intracranial vessel wall enhancement (VWE) scoring system and evaluate its potential as a protocol for monitoring systemic lupus erythematosus (SLE) disease activity and neuropsychiatric impairment.
Materials And Methods: In this retrospective study, fifty patients with SLE underwent conventional MRI and high-resolution magnetic resonance vascular wall imaging (HR-VWI) at three tertiary hospitals between August 2022 and December 2023. We analyzed VWE distribution in intracranial arteries, developed a scoring system based on enhancement patterns, and examined the relationship between VWE scores, disease activity, and cognitive function.
Neonatal lupus erythematosus: an acquired autoimmune disease to be taken seriously.
Ann Med
December 2025
Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Aim: This review aims to summarize the epidemiology, pathogenesis, clinical features, management, prognosis and regression of Neonatal lupus erythematosus (NLE) with a view to providing directions for standardized diagnosis, treatment and further research.
Methods: We conducted a comprehensive literature review of NLE. NLE-related peer-reviewed papers were searched through PubMed/Medline were searched up to November 2024.
Challenges of Managing Lupus Nephritis in an Emerging Nephrology Centre: A Fijian Cohort Study.
Nephrology (Carlton)
March 2025
Department of Internal Medicine, Colonial War Memorial Hospital, Suva, Fiji.
Aim: To characterise the epidemiology and outcomes of Lupus Nephritis (LN) in Fiji.
Methods: All adult LN cases diagnosed from 2016 to 2020 at the national referral hospital were included. Treatment response, kidney failure, dialysis dependence and death were reported.
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