AI Article Synopsis
- The study aimed to compare the effectiveness of a new imaging technique (AlF-NOTA-FAPI-04 PET/CT) against a commonly used method (F-FDG PET/CT) in patients with autoimmune rheumatic diseases (ARDs).
- Out of 58 participants, both imaging methods showed high positive detection rates, with AlF-NOTA-FAPI-04 slightly outperforming F-FDG overall, although F-FDG was more effective in certain areas like lymph nodes and bone marrow.
- The findings suggest that while both techniques are sensitive for diagnosing ARDs, AlF-NOTA-FAPI-04 may have advantages for detecting issues in the lung, muscle, and tendon/ligament in most cases, except for adult
Article Abstract
Objectives: The aim of this study was to determine the performance of radionuclide-labeled fibroblast activation protein inhibitors (AlF-NOTA-FAPI-04) PET/CT in patients with autoimmune rheumatic diseases (ARDs) and compare it with fluorine-18 (F) labeled fluorodeoxyglucose (FDG) imaging.
Methods: Fifty-eight participants with ARDs were prospectively enrolled from April 2022 to February 2024 and underwent dual-tracer PET/CT imaging. For both F-FDG and AlF-NOTA-FAPI-04 PET/CT, imaging findings were interpreted and compared. The clinical significance was compared betweenF-FDG PET/CT and AlF-NOTA-FAPI-04 PET/CT imaging.
Results: F-FDG imaging was positive in 53 out of 58 cases (91.4%) while AlF-NOTA-FAPI-04 imaging was positive in 55 out of 58 cases (94.8%). Overall positive rate of AlF-NOTA-FAPI-04 imaging was as high as F-FDG imaging (P = 0.625). F-FDG imaging detected more lesions in lymph node, spleen, and bone marrow. AlF-NOTA-FAPI-04 imaging detected more lesions in the lung, muscle, and tendon/ligament. There was no statistical difference of composing ratio of grades of clinical significance between two imaging modalities (χ = 2.875, P = 0.238). The superior rate of AlF-NOTA-FAPI-04 PET/CT imaging was higher than F-FDG imaging (P = 0.020). In subgroup of adult-onset Still's disease, F-FDG imaging showed better performance than AlF-NOTA-FAPI-04 imaging. In most of the other subgroup of ARDs, AlF-NOTA-FAPI-04 PET/CT imaging overperformed F-FDG imaging.
Conclusion: Both F-FDG and AlF-NOTA-FAPI-04 PET/CT imaging have excellent sensitivity in ARDs. The detection capabilities of two tracers varied according to the involving organs of ARDs. In most of ARDs except adult-onset Still's disease, AlF-NOTA-FAPI-04 PET/CT imaging overperformed F-FDG imaging. Key Points • F-FDG and Al18F-NOTA-FAPI-04 PET/CT imaging have excellent sensitivity in diagnosing of ARDs. • F-FDG PET/CT imaging detected more lesions in lymph node, spleen, and bone marrow. • F-NOTA-FAPI-04 PET/CT imaging detected more lesions in the lung, muscle, and tendon/ligament. • F-NOTA-FAPI-04 PET/CT imaging overperformedF-FDG in most subgroups of ARDs.
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| http://dx.doi.org/10.1007/s10067-024-07155-4 | DOI Listing |
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