AI Article Synopsis
- The study investigates the genomic characteristics of patients with metastatic prostate cancer (mPC), focusing on the genetic testing and outcomes of these patients across various centers worldwide.
- A total of 349 mPC patients from 12 academic centers in five countries were included, with 66.6% undergoing genomic analysis, primarily through multigene panel analyses and next-generation sequencing.
- The findings reveal important progression-free survival (PFS) data, particularly in the metastatic castration-resistant prostate cancer (mCRPC) group, and contribute valuable insights to the understanding of the genomic landscape of advanced prostate cancer in Latin America, which is often underrepresented in clinical trials.
Article Abstract
Purpose: This study aims to describe genomic characteristics of patients with metastatic prostate cancer (mPC).
Patients And Methods: This study is a retrospective, multicenter cohort study of patients with mPC and reports on genomic testing. Patients were included from 12 academic centers in five countries.
Results: A total of 349 patients with PC were included in this study. Most patients (209, 59.9%) were de novo metastatic. Genomic analysis was performed in 233 (66.6%) patients in the metastatic castration-resistant prostate cancer (mCRPC) setting, and only 115 (32.8%) patients had a tumor evaluation in the metastatic hormone sensitive prostate cancer scenario. The evaluation of somatic and/or germline mutations was performed through multigene panel analyses in 290 (83.09%) patients, and next-generation sequencing of and genes was performed in 59 (16.91%) patients. Analyzing the mCRPC subgroup, with a median follow-up of 15.6 months (IQR, 14-19.06), the median progression-free survival (PFS) was not reached (NR) and the PFS at 16 months was 58.7% (95% CI, 50.8 to 67.8). When comparing patients with mutations with those who are not -mutated in the mCRPC scenario, the median PFS was NR (95% CI, 14 to NR) and 26.3 months (95% CI, 16.7 to 36.5; = .2), respectively. Two of six patients with mutations were treated with targeted therapies (poly-ADP-ribose polymerase inhibitors).
Conclusion: Our study, to the best of our knowledge, represents one of the larger data sets for somatic testing in patients with PC in Latin America (LATAM). It adds valuable information to the growing body of knowledge about the genomic landscape of advanced PC in real-world daily practice scenarios in LATAM countries, which are not always well-represented in large-scale randomized clinical trials.
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| http://dx.doi.org/10.1200/GO.24.00072 | DOI Listing |
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