AI Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to traditional treatments like chemotherapy and radiation, largely due to the influence of oncogenic KRAS, which promotes glucose metabolism and immune suppression in tumors.
- Researchers combined KRAS* inhibitors with immunotherapy agents targeting various immune cells (CXCR1/2 for myeloid cells, anti-LAG3 for T cells, and anti-41BB for dendritic cells) in a mouse model, resulting in significant tumor shrinkage and extended survival for some mice.
- The study demonstrated that this combination therapy improves T cell activity, reduces suppressive myeloid cells, and boosts dendritic cell function in the tumor, suggesting a promising new treatment strategy for
Article Abstract
Clinically available KRAS* inhibitors and IO agents alleviated the immunosuppressive tumor microenvironment in PDAC. Profound tumor regression and prolonged survival in an autochthonous PDAC model provide a compelling rationale for combining KRAS* inhibition with IO agents targeting multiple arms of the immunity cycle to combat PDAC.
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| http://dx.doi.org/10.1158/2159-8290.CD-24-0489 | DOI Listing |
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