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Correction: The influence of lipoprotein(a) on aortic valve calcification in patients undergoing transcatheter aortic valve replacement.

Clin Res Cardiol

January 2025

Clinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum Nordrhein-Westfalen, Ruhr-Universität Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany.

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Article Synopsis
  • - The study focuses on the LPA kringle IV type-2 (KIV-2) VNTR, a repetitive genomic region that is crucial for understanding plasma lipoprotein(a) levels, which are linked to cardiovascular risks and vary between individuals and populations.
  • - Researchers utilized a new method called UMI-ONT-Seq for sequencing, which allowed them to detect single nucleotide polymorphisms (SNPs), map haplotypes, and quantify VNTR units in the KIV-2 region across various human samples.
  • - Results showed that UMI-ONT-Seq effectively identified KIV-2 SNPs at very low levels with high accuracy, and the repeat number of KIV-2 units matched well
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