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Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Published: November 2024
AI Article Synopsis
Risk stratification for patients with drug-induced type-1 Brugada syndrome is difficult, and the usefulness of electrophysiological studies (EPS) is unclear.
A systematic literature search categorized patients into three groups based on EPS results: positive, negative, and no EPS conducted.
The study found no significant differences in the rates of arrhythmia events among these groups over an average follow-up of 5.1 years, suggesting EPS may not enhance long-term prognosis in these patients.
Article Abstract
Background: Risk stratification in drug-induced type-1 Brugada syndrome (BrS) patients is challenging. The role of electrophysiological study (EPS) is debated as the majority of drug-induced type-1 BrS patients would not be studied according to the latest recommendations.
Methods: A complete systematic literature search was performed to gauge the EPS role in this population. Three subgroups were defined: positive-EPS group, negative-EPS group, no-EPS group.
Results: Among 1318 drug-induced type-1 BrS patients, no significant difference in the incidence rate of arrhythmic events was observed between groups (I2 = 45%, P for subgroup difference = 0.10) during a mean follow-up of 5.1 years, also considering symptomatic status.
Conclusion: In long-term follow-up of drug-induced type-1 BrS patients, EPS does not seem to aid prognostic stratification.
