AI Article Synopsis
- A new method has been developed for creating 2-acetamidequinoline-oxides using a Cu(I) catalyst, featuring high regioselectivity.
- The reaction occurs under mild conditions and shows great compatibility with various functional groups.
- Adding hydrochloric acid helps break down copper complexes, making the postprocessing stage easier.
Article Abstract
A Cu(I)-catalyzed highly regioselective synthesis of 2-acetamidequinoline -oxides using dioxazolones with quinoline -oxides has been reported. The reaction possesses mild reaction conditions and excellent functional group compatibility. Furthermore, the addition of hydrochloric acid promotes the decomposition of copper complexes, which is beneficial for postprocessing.
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| http://dx.doi.org/10.1021/acs.orglett.4c03118 | DOI Listing |
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