Background: Lactate is a crucial intermediary, facilitating communication between myocardial energy metabolism and microenvironmental regulation. The present study aimed to investigate the relationship between lactate-related genes (LRGs) and myocardial infarction (MI).
Methods: A total of 23 LRGs exhibited differential expression between individuals with MI and healthy controls. Lasso regression analysis and validation with the GSE61144 dataset identified three hub genes: COX20, AGK, and PDHX. Single-gene GSEA of these genes revealed strong enrichment in pathways related to amino acid metabolism, cell cycle, and immune functions. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was utilized to validate the expression levels of the hub genes.
Results: Immune infiltration analysis revealed differences in CD4 T and CD8 T cells between the MI and control groups. Additionally, 67 candidate drugs targeting the three hub LRGs were identified, and a ceRNA network was constructed to explore the intricate interactions among these genes.
Conclusions: These findings enhance the understanding of MI and have potential therapeutic implications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437837 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e38152 | DOI Listing |
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