AI Article Synopsis
- PFAS are a group of environmental pollutants linked to health issues, particularly disrupting thyroid functions.
- The study reveals that mid- to long-chain PFAS can inhibit the synthesis of the thyroid hormone T4 by altering hydrogen bond networks and the orientation of residues necessary for hormone production.
- Sulfonic PFAS are found to be more toxic and impactful on thyroid function than carboxylic PFAS, indicating specific PFAS types pose greater risks to thyroid health.
Article Abstract
Per- and polyfluoroalkyl substances (PFAS) are a group of environmental pollutants that have been linked to a variety of health problems in humans, including the disruption of thyroid functions. Herein, for the first time, the impact of PFAS on thyroid hormone synthesis is shown. Mid- to long-chain PFAS impact thyroid hormone synthesis by changing the local hydrogen bond network as well as the required orientation of hormonogenic residues, stopping the production of thyroxine (T4). Furthermore, the toxic effects of sulfonic PFAS are more prominent than those of carboxylic PFAS, highlighting that the exposure to these specific compounds can pose greater problems for thyroid homeostasis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11425649 | PMC |
| http://dx.doi.org/10.1021/acsomega.4c03578 | DOI Listing |
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