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Activation of proresolving macrophages in dorsal root ganglia attenuates persistent arthritis pain.
Proc Natl Acad Sci U S A
March 2025
Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, Guys' Campus, London SE1 1UL, United Kingdom.
Pain independent of disease activity is frequently reported by rheumatoid arthritis patients and remains undertreated. Preclinical evidence suggests that imbalance of neuroimmune proresolving interactions within dorsal root ganglia (DRG) rather than at the site of inflammation plays mechanistic roles in persistent arthritis pain. Here, we inhibited production of proresolving lipid mediators by silencing 12/15-lipoxygenase expression in CX3CR1 monocyte/macrophages conditional knockout (cKO) mice.
View Article and Find Full Text PDFImmune-enhancing effects of enzymatic hydrolysates of peanut sprouts in RAW 264.7 macrophages and cyclophosphamide-induced immunosuppressed mouse model.
Food Res Int
March 2025
Division of Functional Food Research, Korea Food Research Institute, 245 nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Republic of Korea; Department of Food Biotechnology, University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address:
Immune deficiency is associated with the development of various diseases. Resveratrol, the main bioactive component of peanut sprouts, exerts immunomodulatory effects. Enzymatic hydrolysis increases the yield of bioactive components from plant resources.
View Article and Find Full Text PDFAcetylsalicylic acid aggravates anaphylaxis in a PGE2-dependent manner.
J Clin Invest
March 2025
Division of Allergy and Immunology, Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Acetylsalicylic acid (ASA) can exert proanaphylactic effects, but the extent of this phenomenon and its underlying mechanisms are undefined. Yet, low homeostatic prostaglandin E2 (PGE2) levels have been associated with anaphylaxis. In this study, we investigated whether the proanaphylactic effect of ASA is PGE2 dependent.
View Article and Find Full Text PDFDirect neutrophil and T cell contact with macrophages induces release of phagosomally processed PAMPs via eructophagy.
J Cell Sci
February 2025
Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Canada.
Macrophages play a pivotal role in clearing debris and microbes from the microenvironment via phagocytosis and orchestrating local inflammation. While mostly understood to be through the synthesis and secretion of soluble mediators such as cytokines and eicosanoids, it has been recently proposed that macrophages can release previously phagocytosed and processed PAMPs and DAMPs into the local microenvironment via a process termed eructophagy, and that these, in turn, can activate recently vicinal leukocytes. Additionally, it has been commonly observed that local macrophages physically interact with other leukocytes, such as neutrophils and T cells, recruited to sites of inflammation.
View Article and Find Full Text PDFInhibition of DYRK1B BY C81 impedes inflammatory processes in leukocytes by reducing STAT3 activity.
Cell Mol Life Sci
February 2025
Institute of Pharmaceutical Biology, Goethe University Frankfurt, Frankfurt, Germany.
Chronic inflammatory diseases are a significant global burden and are associated with dysregulated resolution of inflammation. Therefore, promoting the process of resolution is a promising therapeutic approach. This study presents the potent anti-inflammatory and pro-resolving effects of a natural product-derived compound called C81.
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