AI Article Synopsis
- Closed-incision negative pressure wound therapy (ciNPWT) is evaluated for its effectiveness in reducing complications after implant-based breast reconstruction in patients who have undergone radiotherapy.
- A study of 301 reconstructions showed that ciNPWT significantly decreased infection rates to 0% compared to 10.4% in the non-ciNPWT group, and wound complications were lower at 1.9% vs. 11.2%.
- The findings indicate that ciNPWT could improve postoperative outcomes and possibly reduce costs for patients undergoing this type of breast reconstruction following radiotherapy.
Article Abstract
Background: Implant-based breast reconstruction following radiotherapy can lead to significant postoperative complications. Closed-incision negative pressure wound therapy (ciNPWT) has emerged as a potential intervention to reduce these complications.
Objectives: To assess the effectiveness of ciNPWT in reducing postoperative complications in patients undergoing implant-based breast reconstruction after radiotherapy.
Methods: A retrospective single-center cohort study was conducted, including patients who underwent implant-based breast reconstruction after mastectomy and radiotherapy between January 1, 2015, and December 31, 2022. We utilized a procedure-level analysis model with patients contributing distinct observations for multiple procedures. Our primary outcome measures included fluid collection, infection, and wound complications. Propensity score analysis was employed to adjust for potential confounders, such as BMI, smoking history, and diabetes history, creating a balanced comparison between the ciNPWT-treated and untreated groups.
Results: In our study of 301 breast reconstructions postradiotherapy from 2015 to 2022, encompassing 218 unique patients, we found significant benefits of ciNPWT. During an average of 2.2-year follow-up, the ciNPWT group demonstrated no infections, contrasting with a 10.4% rate in the non-ciNPWT group ( < .0001). Wound complications were also significantly lower in the ciNPWT group (1.9% vs 11.2%; = .00848). Demographic differences were adjusted using inverse probability of treatment weights. The findings suggest ciNPWT's promising role in enhancing postoperative outcomes in breast reconstruction postradiotherapy.
Conclusions: Our study suggests that the use of ciNPWT in implant-based breast reconstruction postradiotherapy can potentially reduce postoperative complications. This intervention can improve patient outcomes and may offer cost-saving benefits in the long run.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427947 | PMC |
| http://dx.doi.org/10.1093/asjof/ojae073 | DOI Listing |
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