Objective: The purpose of this retrospective study was to look into patterns in the diagnosis and treatment of oral mucosal disorders over a 12-year period in a tertiary care environment.
Methods: A comprehensive review of medical records from a Tertiary Care Center was conducted, encompassing 2010-2022. Data on patient demographics, clinical presentations, diagnostic methods, treatment modalities, and outcomes were systematically analyzed. Descriptive statistics and trend analyses were employed to discern patterns and changes over time.
Results: A total of 500 cases were included in the research, with a mean age of 42.5 years. Aphthous ulcers, oral lichen planus, and candidiasis were the predominant diseases, collectively constituting 58% of cases. Diagnostic modalities varied, including biopsy and imaging. Treatment modalities ranged from topical agents to surgical procedures, tailored to specific diagnoses. The prevalence of squamous cell carcinoma was noteworthy at 8%.
Conclusion: This research provides insights into the evolving landscape of oral mucosal disease diagnosis and treatment in tertiary care. Identified trends emphasize the importance of individualized care, advancements in diagnostic techniques, and ongoing research collaboration. Addressing challenges identified in this research is crucial for enhancing patient outcomes and shaping future research directions.
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http://dx.doi.org/10.4103/jpbs.jpbs_294_24 | DOI Listing |
Clin Exp Dermatol
January 2025
Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Clin Exp Immunol
January 2025
Bill & Melinda Gates Foundation, Seattle, WA, USA.
Oral vaccines have several advantages compared with parenteral administration: they can be relatively cheap to produce in high quantities, easier to administer, and induce intestinal mucosal immunity that can protect against infection. These characteristics have led to successful use of oral vaccines against rotavirus, polio, and cholera. Unfortunately, oral vaccines for all three diseases have demonstrated lower performance in the highest-burden settings where they are most needed.
View Article and Find Full Text PDFCurr Med Imaging
January 2025
Department of Nuclear Medicine, Hangzhou Cancer Hospital, Hangzhou 310002, China.
Background: Cytomegalovirus (CMV) infection is common in the digestive and central nervous systems and can infect the entire digestive tract from the mouth to the rectum. In immunocompromised patients, CMV infection is prone to develop into CMV disease, especially in Acquired Immune Deficiency Syndrome (AIDS) patients. Severe cases may accelerate the progression of AIDS patients and form systemic CMV infection.
View Article and Find Full Text PDFVaccines (Basel)
December 2024
Laboratorio de Vacunas Veterinarias, Departamento de Ciencias Biológicas Animales, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santa Rosa 11735, La Pintana, Santiago 8820808, Chile.
Immunization against Gonadotropin-Releasing Hormone (GnRH) has been successfully explored and developed for the parenteral inoculation of animals, aimed at controlling fertility, reducing male aggressiveness, and preventing boar taint. Although effective, these vaccines may cause adverse reactions at the injection site, including immunosuppression and inflammation, as well as the involvement of laborious and time-consuming procedures. Oral vaccines represent an advancement in antigen delivery technology in the vaccine industry.
View Article and Find Full Text PDFVaccines (Basel)
December 2024
Hainan Institute of Northwest A&F University, Sanya 572024, China.
is a common opportunistic pathogen that causes gastrointestinal diseases in livestock and poultry. Our preliminary research has demonstrated that administering oral yeast-cell microcapsule (YCM)-mediated DNA vaccines can effectively stimulate mucosal immunity, thereby preventing the occurrence of gastrointestinal diseases. In this study, the α-toxin gene was first cloned and the H126G and C-terminal (C247-370) mutations were created.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!