AI Article Synopsis
- The study investigates the unexplained causes of oral lichen planus (OLP), which is linked to an immune response involving T-cells, by examining the role of oral microorganisms.
- Researchers analyzed 82 tissue samples from OLP patients and 20 from healthy individuals using immunohistochemistry to identify specific microorganisms.
- The findings revealed that various microorganisms, including certain periodontopathogenic bacteria and human papillomavirus types 16 and 18, were more frequently present in OLP patients than in healthy controls, suggesting a potential connection to the condition's development.
Article Abstract
Background: The pathophysiology and etiology of oral lichen planus (OLP) are still unknown, despite the fact that the condition's progression has been connected to a T-cell-based immune response. Research has focused on variables, such as oral bacteria, that may cause an autoimmune reaction with conflicting results.
Aim: This study was conducted to evaluate the role of oral microorganisms in the pathogenesis of OLP.
Materials And Methods: In this study, 82 formalin-fixed paraffin-embedded specimens of histopathologically confirmed cases of OLP and 20 such specimens of normal healthy subjects were obtained. Immunohistochemistry was carried out for the identification of microorganisms.
Results: was observed in 47.12% of OLP cases and 9.43% of healthy controls. was discovered in 45.21% of OLP cases and 13.46% of healthy controls. Periodontopathogenic bacteria was found in 33.14% of OLP cases and 13.45% of healthy controls. Human papillomavirus (HPV)-16 was noticed in 38.12% of OLP cases and 11.24% in the control group. HPV-18 was found in 32.43% of OLP patients and 11.43% in the control group. was found in 46.47% of OLP patients and 6.45% in control.
Conclusion: It was observed that several microorganisms like , , , periodontopathogenic bacteria, HPV-16, and HPV-18 were found to be related to OLP.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11426837 | PMC |
| http://dx.doi.org/10.4103/jpbs.jpbs_90_24 | DOI Listing |
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