AI Article Synopsis
- The case report discusses a 46-year-old man who experienced severe complications, including respiratory distress and recurrent cardiac arrhythmias, after overdosing on carbamazepine.
- A coronary angiography revealed a spasm in the left coronary artery, which was treated effectively with nitroglycerin, leading to improved cardiac function and stabilization.
- This case highlights the importance of timely cardiological evaluation in overdose situations to direct immediate and appropriate treatment, ultimately resulting in the patient's recovery.
Article Abstract
Background: Overdoses of carbamazepine may occur due to various reasons. The summary of product characteristics of carbamazepine includes information about the possibility of side effects after taking this drug. However, the symptoms described do not include coronary vasospasm, which occurred in the case described. Making such a diagnosis is a key element in therapeutic management, as it changes further clinical decisions.
Case Summary: A 46-year-old patient was admitted to the hospital for disorders of consciousness following an overdose of carbamazepine. On the second day, the patient exhibited respiratory distress. Subsequently, the patient was transferred to the intensive care unit, intubated, and placed on mechanical ventilation. On the same day, the patient experienced recurrent cardiac arrhythmias in the form of pulseless ventricular tachycardia and ventricular fibrillation; the patient was resuscitated and defibrillated eight times. Due to a rapid decline in cardiac output coupled with persistent electrocardiographic changes and haemodynamic instability, the patient underwent urgent coronary angiography. The procedure revealed a spasm in the initial segment of the circumflex branch of the left coronary artery, which subsequently resolved following nitroglycerin administration. Subsequent to the implementation of this therapeutic approach, a reduction in the demand for norepinephrine and dobutamine was achieved. In the following days, the patient's general condition improved. The patient was discharged home while maintaining full cognitive capacity and cardiovascular and respiratory fitness.
Discussion: In the case described, the expeditious performance of a cardiological diagnostic evaluation played a pivotal role in achieving therapeutic success, enabling the prompt initiation of appropriate treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437652 | PMC |
| http://dx.doi.org/10.1093/ehjcr/ytae488 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Marine and atmospheric transport modeling supporting nuclear preparedness in Norway: Recent achievements and remaining challenges.
Sci Total Environ
January 2025
Center for Environmental Radioactivity (CERAD) CoE, Norwegian University of Life Sciences, P.O. Box 5003, N-1432 Ås, Norway; Faculty of Environmental Sciences and Natural Resource Management, Norwegian University of Life Sciences (NMBU), P.O.Box 5003, NO-1432 Ås, Norway.
Numerical transport models are important tools for nuclear emergency decision makers in that they rapidly provide early predictions of dispersion of released radionuclides, which is key information to determine adequate emergency protective measures. They can also help us understand and describe environmental processes and can give a comprehensive assessment of transport and transfer of radionuclides in the environment. Transport of radionuclides in air and ocean is affected by a number of different physico-chemical processes.
View Article and Find Full Text PDFAssociation of Subcapsular Liver Hematoma With Preeclampsia, Eclampsia, or Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome.
Obstet Gynecol
January 2025
Division of Maternal-Fetal Medicine, Department of Obstetrics Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas.
Objective: To describe the presentation, outcomes, and management strategies for cases of subcapsular liver hematoma associated with preeclampsia, eclampsia, or HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome.
Methods: This was a case series of individuals with subcapsular liver hematoma managed at a single level IV center over a 10-year period, from 2013 to 2024. Presenting signs and symptoms, laboratory findings, time of onset, management strategies, acute perinatal and maternal outcomes, and long-term outcomes such as subsequent pregnancies were reviewed in the medical record and recorded.
NR2E3-Associated Retinopathy Presenting with Bilateral Choroidal Neovascularization.
Retin Cases Brief Rep
October 2024
Singapore National Eye Centre, Singapore.
Purpose: We describe an atypical presentation of an 11-year-old female with enhanced S-cone syndrome (ESCS).
Methods: Case report. The patient underwent a thorough ophthalmic examination and investigations such as colour fundus photography, optical coherence tomography, fundus autofluorescence, fluorescein and indocyanine angiography, an electroretinogram and genetic testing.
FDG PET/CT in a Case of Gardner Syndrome.
Clin Nucl Med
December 2024
From the Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine.
Gardner syndrome is characterized by multiple intestinal polyps and extraintestinal lesions. We describe FDG PET/CT findings of the extraintestinal lesions in a patient with Gardner syndrome. FDG PET/CT showed 2 hypermetabolic desmoid tumors in the abdominal wall, sclerotic areas with multifocal activity in the maxilla and mandible, multiple osteomas in the bilateral parietal, left frontal, sphenoid and ethmoid bones, an impacted tooth in the right maxilla, and bone islands in the T2 and T5 vertebral bodies.
View Article and Find Full Text PDFApplication of Reverse Sural Flaps in Pediatric Patients: A Systematic Review.
Ann Plast Surg
December 2024
Division of Plastic Surgery, University of Texas Medical Branch, Galveston, TX.
Introduction: The reverse sural flap (RSF) is a random-type, pedicled flap based on sural artery perforators indicated for traumatic lower-extremity wounds. The RSF has demonstrated comparable results to free flap placement in the adult population for reconstruction of distal third defects, but few reports describe its application and outcomes in the pediatric population.
Methods: We investigated RSF application in pediatric patients (<18 years of age) through systematic review and meta-analysis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!