AI Article Synopsis
- * Researchers sequenced the genomes of 25 isolates from Central and East Africa, revealing that these isolates are mostly monoclonal and show genetic patterns that correlate with geographical locations.
- * Results indicated that one species has lower genetic diversity than the other, and both exhibit signs of selective pressures on specific genes, suggesting that their evolutionary paths and responses to control measures in malaria have unique aspects based on their history.
Article Abstract
( and () are relapsing malaria parasites endemic to Africa and Asia that were previously thought to represent a single species. Amid increasing detection of ovale malaria in sub-Saharan Africa, we performed a population genomic study of both species across the continent. We conducted whole-genome sequencing of 25 isolates from Central and East Africa and analyzed them alongside 20 previously published African genomes. Isolates were predominantly monoclonal (43/45), with their genetic similarity aligning with geography. showed lower average nucleotide diversity (1.8×10) across the genome compared to (3.0×10) (p < 0.0001). Signatures of selective sweeps involving the dihydrofolate reductase gene were found in both species, as were signs of balancing selection at the merozoite surface protein 1 gene. Differences in the nucleotide diversity of and may reflect unique demographic history, even as similar selective forces facilitate their resilience to malaria control interventions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11429939 | PMC |
| http://dx.doi.org/10.1101/2024.04.10.588912 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Return to work of major trauma survivors from a private level 1 trauma centre in South Africa.
Eur J Trauma Emerg Surg
January 2025
Division of Physiotherapy, Department of Health and Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Purpose: Trauma is known as a leading cause of mortality and injury related disability globally. In South Africa (SA) the socioeconomic burden of trauma is magnified as the working age is most affected. The aim of this study was to describe the proportion of major trauma survivors who returned to work (RTW) during a 6-month period post hospital discharge and to identify the factors associated with the RTW outcome.
View Article and Find Full Text PDFTrypanosomosis and Transhumance: Contributions to Contemporary Conflicts Between Farmers and Herdsmen Along the Tsetse Fly Belts: Mathematical Modeling and Systematic Field Analysis Approach.
Acta Biotheor
January 2025
Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
Conflicts within the tsetse fly belt revealed a strong correlation between the dynamics of bovine trypanosomosis and the insurgency involving farmers and herders in Nigeria and parts of West Africa. This study examined the history, causes and influence of farmers-herdsmen conflicts on banditry, terrorism and food security as it relates to the epidemiology of African animal trypanosomosis (AAT). A combination of literature database searches, semi-structured questionnaires, and mathematical modeling was employed.
View Article and Find Full Text PDFEnzootic Ovine Abortion among small ruminants in Southern Benin.
Vet Ital
January 2025
University Hospital College, University of Ibadan, Nigeria.
The advancement of small ruminant farming in Benin has encountered challenges associated with health issues and agricultural practices. This study aimed to provide the initial documentation of the prevalence of enzootic ovine abortion and evaluate the health status of animals concerning various recurring diseases on traditional small ruminant farms in Benin. In 2023, a semi-structured survey of 450 farms was carried out in two agricultural development centers in Benin.
View Article and Find Full Text PDFZoonotic Disease: Knowledge, Attitude and Practice of Dairy Farm Owner in Wolaita Sodo District, Ethiopia.
Vet Med Sci
January 2025
College of Veterinary Medicine and Animal Science, Samara University, Samara, Ethiopia.
Background: Lack of knowledge regarding zoonotic transmission, prevention and control measures is a potential high risk for the occurrence of zoonotic diseases.
Objective: The study aimed to assess knowledge, attitude and practices of dairy farm participants concerning zoonoses.
Animals: A cross-sectional study was conducted from March to August 2022 in and around Sodo town, using a questionnaire among dairy farm participants (n = 123).
Mycotoxin management in Sub-Saharan Africa: A comprehensive systematic review of policies and strategies in Malawi.
Toxicol Rep
June 2025
Browns Consulting Company PO Box 274, Rumphi, Malawi.
Food safety challenges, such as mycotoxin contamination, pose severe threats to public health, agricultural productivity, and economic development across Sub-Saharan African countries and beyond. This study investigated whether government policies related to food safety adequately address these concerns, using Malawi as a case study. We systematically reviewed 29 government-authored policy documents related to food safety.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!