AI Article Synopsis
- Trigger valves are essential components in microfluidic systems that control fluid flow by stopping it at expansions and allowing release through connected channels.
- This study successfully implements trigger valves in open channels and demonstrates how multiple valves can create layered capillary flow alongside main channels.
- A model for flow dynamics at these valves was developed and validated, with implications for applications in biosensing, sample preparation, hydrogel patterning, and organ-on-a-chip technologies.
Article Abstract
Trigger valves are fundamental features in capillary-driven microfluidic systems that stop fluid at an abrupt geometric expansion and release fluid when there is flow in an orthogonal channel connected to the valve. The concept was originally demonstrated in closed-channel capillary circuits. We show here that trigger valves can be successfully implemented in open channels. We also show that a series of open-channel trigger valves can be placed alongside or opposite a main channel resulting in a layered capillary flow. We developed a closed form model for the dynamics of the flow at trigger valves based on the concept of average friction length and successfully validated the model against experiments. For the main channel, we discuss layered flow behavior in the light of the Taylor-Aris dispersion theory and in the channel turns by considering Dean theory of mixing. This work has potential applications in autonomous microfluidics systems for biosensing, at-home or point-of-care sample preparation devices, hydrogel patterning for 3D cell culture and organ-on-a-chip models.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11429806 | PMC |
| http://dx.doi.org/10.1101/2024.09.17.613325 | DOI Listing |
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