AI Article Synopsis
- The gut-brain axis enables communication between the intestine and nervous system, crucial for maintaining overall health.
- Researchers discovered that a specific peptide, FLP-2, from the intestine enhances the antioxidant response by triggering the release of another neuropeptide, FLP-1, from neurons.
- This process is influenced by hydrogen peroxide levels, which promote FLP-2 secretion, thereby linking intestinal health to nervous system activity and oxidative stress management.
Article Abstract
The gut-brain axis mediates bidirectional signaling between the intestine and the nervous system and is critical for organism-wide homeostasis. Here we report the identification of a peptidergic endocrine circuit in which bidirectional signaling between neurons and the intestine potentiates the activation of the antioxidant response in in the intestine. We identify a FMRF-amide-like peptide, FLP-2, whose release from the intestine is necessary and sufficient to activate the intestinal oxidative stress response by promoting the release of the antioxidant FLP-1 neuropeptide from neurons. FLP-2 secretion from the intestine is positively regulated by endogenous hydrogen peroxide (HO) produced in the mitochondrial matrix by /superoxide dismutase, and is negatively regulated by /peroxiredoxin, which depletes HO in both the mitochondria and cytosol. HO promotes FLP-2 secretion through the DAG and calciumdependent protein kinase C family member and by the SNAP25 family member in the intestine. Together, our data demonstrate a role for intestinal HO in promoting inter-tissue antioxidant signaling through regulated neuropeptide-like protein exocytosis in a gut-brain axis to activate the oxidative stress response.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11429608 | PMC |
| http://dx.doi.org/10.1101/2024.04.03.587937 | DOI Listing |
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