AI Article Synopsis

  • The study investigates how trace mineral intake (specifically zinc, copper, and manganese) relates to coronary artery disease (CAD) in individuals with and without dyslipidaemia (DL).
  • Conducted in Shika town, Japan, the research involved 895 middle-aged and older adults after excluding those genetically predisposed to high cholesterol.
  • Findings indicate that low intake of these trace minerals is linked to a higher risk of CAD in individuals with DL, suggesting a potentially significant relationship that needs further research over time.

Article Abstract

Although the relationship between dyslipidaemia (DL) and coronary artery disease (CAD) or between trace minerals intake and CAD is well known separately, the exact nature of this relationship remains unknown. We hypothesize that the relationship between trace mineral intake and CAD may differ depending on whether or not the individual has DL. The present study analysed the relationships among trace mineral intake, DL, and CAD in middle-aged and older adults living in Shika town, Ishikawa prefecture, Japan. This study included 895 residents following the exclusion of those with genetic risk carriers for familial hypercholesterolemia. Trace mineral intake was evaluated using the brief-type self-administered diet history questionnaire. Interactions were observed between DL and CAD with zinc ( = 0.004), copper ( = 0.010), and manganese intake ( < 0.001) in a two-way analysis of covariance adjusted for covariates such as sex, age, body mass index, and current smokers and drinkers. Multiple logistic regression analysis showed that zinc (odds ratio (OR): 0.752; 95% confidence interval (CI): 0.606, 0.934; = 0.010), copper (OR: 0.175; 95% CI: 0.042, 0.726; = 0.016), and manganese (OR: 0.494; 95% CI: 0.291, 0.839; = 0.009) were significant independent variables for CAD in the dyslipidaemic group. The present results suggest that DL with a low trace mineral intake is associated with CAD. Further longitudinal studies are required to confirm this relationship.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11428112PMC
http://dx.doi.org/10.1017/jns.2024.26DOI Listing

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