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Nighttime safety of daridorexant: Evaluation of responsiveness to an external noise stimulus, postural stability, walking, and cognitive function.
J Psychopharmacol
December 2024
Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Background: Daridorexant is a dual orexin receptor antagonist approved for the treatment of chronic insomnia disorder.
Aims: Investigate the auditory awakening threshold (AAT), postural stability, and cognitive function during the night following evening administration of daridorexant 25 and 50 mg.
Methods: Double-blind, placebo-controlled, randomized, 3-way (placebo, 25, 50 mg) crossover study in 36 healthy male and female nonelderly adult and elderly subjects (1:1 sex/age ratio).
Awakening to the Pertinence of Sleep for Hypertension.
Hypertension
December 2024
University Health Network and Sinai Health Division of Cardiology, Toronto General Hospital Research Institute, and the Lunenfeld-Tanenbaum Research Institute, Faculty of Medicine, University of Toronto, Canada (T.T., J.S.F.).
Stem Cell Origin of Cancer: Implications of Oncogenesis Recapitulating Embryogenesis in Cancer Care.
Cancers (Basel)
April 2023
Department of Urology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
From this perspective, we wonder about the clinical implications of oncology recapturing ontogeny in the contexts of neoantigens, tumor biomarkers, and cancer targets. We ponder about the biological ramifications of finding remnants of mini-organs and residuals of tiny embryos in some tumors. We reminisce about classical experiments showing that the embryonic microenvironment possesses antitumorigenic properties.
View Article and Find Full Text PDFReward sensitivity modulates the brain reward pathway in stress resilience via the inherent neuroendocrine system.
Neurobiol Stress
September 2022
Faculty of Psychology, Southwest University, Chongqing, 400715, China.
In the previous 10 years, researchers have suggested a critical role for the brain reward system in stress resilience. However, no study has provided an empirical link between activity in the mesostriatal reward regions during stress and the recovery of cortisol stress response. Moreover, although reward sensitivity as a trait has been demonstrated to promote stress resilience, it remains unclear whether it modulates the brain reward system in stress resilience and how this effect is achieved by the inherent neuroendocrine system.
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