Pyrazole based palladacycles for the synthesis of β-aminoketones by redox coupling of allyl alcohols and anilines.

Org Biomol Chem

School of Chemical Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar, an OCC of Homi Bhabha National Institute, Bhubaneswar 752050, Odisha, India.

Published: October 2024

Herein, we report the synthesis of β-aminoketones by oxidative coupling of allyl alcohols at room temperature using a pyrazole based palladacycle and BINOL-phosphoric acid system. This method avoids the use of any base, external oxidant, and additive. The reaction of -anisidine and 1-penten-3-ol under the optimized conditions using isolated palladacycle-BINOL-phosphoric acid produced the desired product in 24 h, which suggests that the active species involved in this reaction is the palladacycle-BINOL-phosphoric acid.

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Source
http://dx.doi.org/10.1039/d4ob01232aDOI Listing

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