AI Article Synopsis
- * Tepotinib, a selective MET inhibitor, showed effectiveness in treating a 60-year-old man with advanced lung adenocarcinoma who had this mutation, leading to significant tumor shrinkage and a remarkable pathological response after surgery.
- * This case suggests tepotinib's potential as a neoadjuvant therapy for NSCLC with METex14 mutations, indicating the need for more clinical trials to explore its feasibility in perioperative settings.
Article Abstract
Mesenchymal-epithelial transition (MET) exon 14 (METex14) skipping mutation is a rare (3%-4%) driver mutation in non-small cell lung cancer (NSCLC). Tepotinib, a selective MET inhibitor, has shown promise in treating METex14 skipping-mutated NSCLC. However, its feasibility for perioperative application remains unclear. This report describes a 60-year-old man with stage IIIA (cT2N2M0) lung adenocarcinoma harboring a METex14 skipping mutation. After initial treatment with savolitinib was discontinued due to grade 4 transaminitis, the patient was switched to tepotinib, resulting in significant tumor regression. Six months later, further shrinkage was observed, and surgery revealed remarkable pathological response with no residual tumor in lymph nodes (ypT2N0M0, IB). Postoperative tepotinib continued, with no relapse at 6-month follow-up. This case highlights the potential of tepotinib as neoadjuvant therapy for resectable METex14 skipping-mutated NSCLC, warranting further clinical trials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554545 | PMC |
| http://dx.doi.org/10.1111/1759-7714.15459 | DOI Listing |
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