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A multidisciplinary view of flash irradiation. | LitMetric

A multidisciplinary view of flash irradiation.

Cancer Radiother

Institut Curie, Research Division, Inserm U 1021-CNRS UMR 3347, université Paris-Saclay, université PSL, centre universitaire, 91401 Orsay cedex, France. Electronic address:

Published: October 2024

AI Article Synopsis

Article Abstract

The delivery of ultra-high dose rates of radiation, called flash irradiation or flash-RT, has emerged as a new modality of radiotherapy shaking up the paradigm of proportionality of effect and dose whatever the method of delivery of the radiation. The hallmark of flash-RT is healthy tissue sparing from the side effects of radiation without decrease of the antitumor efficiency in animal models. In this review we will define its specificities, the molecular mechanisms underlying the flash effect and the ongoing developments to bring this new modality to patient treatment.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canrad.2024.07.003DOI Listing

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