Histiocytic neoplasms: a brief review and differential diagnosis.

J Clin Exp Hematop

Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Published: September 2024

AI Article Synopsis

  • - Histiocytic neoplasms (HNs) encompass various diseases like juvenile xanthogranuloma and Erdheim-Chester disease, which are recognized in the WHO's latest classification.
  • - These diseases have unique clinical and histological characteristics, but they share a common feature of histiocytic cell proliferation, leading to similarities in appearance.
  • - The review summarizes clinical data, molecular aspects, histological features, and immunophenotyping of HNs, while also addressing the need for differentiating them from other similar conditions.

Article Abstract

Histiocytic neoplasms (HNs) include juvenile xanthogranuloma, Erdheim-Chester disease, Rosai-Dorfman disease, ALK-positive histiocytosis, and histiocytic sarcoma in the 5th edition of the World Health Organization Classification of Haematolymphoid Tumours. These entities are clinicopathologically distinctive, and typical histological findings have been established. However, the common feature of a proliferation of histiocytic cells often leads to morphological overlap among HNs, and also necessitates a differential diagnosis from several non-HNs or non-neoplastic conditions. In this review, we provide a brief summary of the clinical findings, molecular features, histopathologies, and immunophenotypes of HNs, as well as to discuss their differential diagnosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528248PMC
http://dx.doi.org/10.3960/jslrt.24031DOI Listing

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