TERRA long noncoding RNAs play key roles in telomere function and maintenance. They can orchestrate telomeric chromatin remodeling, regulate telomere maintenance by telomerase and homology-directed repair, and they participate in the telomeric DNA damage response. TERRA associates with chromosome ends through base-pairing forming R-loops, which are mediated by the RAD51 DNA recombinase and its partner RAD51AP1. Telomeric R-loops interfere with replication fork progression, stimulating a switch of telomere maintenance from semiconservative DNA replication to homology-directed repair (HDR). The latter mechanism is exploited by a subset of cancer cells that lack telomerase, referred to as ALT. In addition, TERRA stimulates HDR at short telomeres during aging, delaying cellular senescence. During carcinogenesis, when cells with eroded telomeres enter replicative crisis, TERRA acts as a signaling molecule to mediate autophagic cell death.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ceb.2024.102437 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Response of YPM x Ross 708 male broilers to diets containing varying inclusions of phytase, calcium butyrate, and bacitracin methylene disalicylate from 1 to 42 d of age-part 1: performance, processing yields, and nutrient digestibility.
Poult Sci
December 2024
Department of Poultry Science, Auburn University, Auburn, AL 36849, USA. Electronic address:
This 42-d study evaluated the effects of phytase, calcium butyrate (CB), and bacitracin methylene disalicylate 50 (BMD) on broiler performance, processing yields, and nutrient digestibility. Ross YPM x 708 male broilers (2,880 total) were distributed in 72 floor pens and assigned to 1 of 9 treatments (8 replicates/treatment) on d of hatch. This experiment was a 2 × 4 + 1 factorial arrangement, including 2 phytase concentrations (500 or 1,500 FTU/kg), 4 microbiota modulating feed additive groups (MMFA; none, CB (0.
View Article and Find Full Text PDFMultilocus Sequence Typing of in Commercial Broiler Flocks.
Avian Dis
December 2022
Department of Poultry Science, Auburn University, Auburn, AL 36849,
About 35% of all broiler flocks in the United States receive an anticoccidial vaccine, but it is not possible to easily differentiate vaccine strains from field isolates. Being able to do that would allow using vaccines in a more targeted way. The objective of this study was to collect isolates from broiler flocks that received anticoccidial feed additives and flocks that had been vaccinated against coccidia and then test them with a multilocus sequencing typing (MLST) scheme developed for this study.
View Article and Find Full Text PDFInfection with Does Not Significantly Alter Intestinal Microbiota and Is Cleared After Changes in the Expression of Cytokines.
Avian Dis
June 2022
Department of Poultry Science, Auburn University, Auburn, AL 36849,
Because of the trend of cage-free egg production, infections with the nematode are receiving increased attention. The aim of this study was to establish a timeline for the influence of on the expression of key cytokines related to a parasitic immune response, and on the composition of the jejunal microbiota. Twenty-eight male layer-type birds were challenged at 24, 25, and 26 days of age.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!