Single-vehicle crashes, particularly those caused by speeding, result in a disproportionately high number of fatalities and serious injuries compared to other types of crashes involving passenger vehicles. This study aims to identify factors that contribute to driver injury severity in single-vehicle crashes using machine learning models and advanced econometric models, namely mixed logit with heterogeneity in means and variances. National Crash data from the Crash Report Sampling System (CRSS) managed by the National Highway Traffic Safety Administration (NHTSA) between 2016 and 2018 were utilized for this study. XGBoost and Random Forest models were employed to identify the most influential variables using SHAP (Shapley Additive Explanations), while a mixed logit model was utilized to model driver injury severity accounting for unobserved heterogeneity in the data collection process. The results revealed a complex interplay of various factors that contribute to driver injury severity in single-vehicle crashes. These factors included driver characteristics such as demographics (male and female drivers, age below 26 years and between 35 and 45 years), driver actions (reckless driving, driving under the influence), restraint usage (lap-shoulder belt usage and unbelted), roadway and traffic characteristics (non-interstate highways, undivided and divided roadways with positive barriers, curved roadways), environmental conditions (clear and daylight conditions), vehicle characteristics (motorcycles, displacement volumes up to 2500 cc and 5,000-10,000 cc, newer vehicles, Chevy and Ford vehicles), crash characteristics (rollover, run-off-road incidents, collisions with trees), temporal characteristics (midnight to 6 AM, 10 AM to 4 PM, 4th quarter of the analysis period: October to December, and the analysis year of 2017). The findings emphasize the significance of driving behavior and roadway design to speeding behavior. These aspects should be given high priority for driver training as well as the design and maintenance of roadways by relevant agencies.
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http://dx.doi.org/10.1038/s41598-024-73134-z | DOI Listing |
Traffic Inj Prev
January 2025
School of Traffic & Transportation Engineering, Changsha University of Science & Technology, Changsha, Hunan, China.
Objective: This study aims to investigate the causes of 2-vehicle collisions involving an autonomous vehicle (AV) and a conventional vehicle (CV). Prior research has primarily focused on the causes of crashes from the perspective of AVs, often neglecting the interactions with CVs.
Method: To address this limitation, the study proposes a classification framework for crash causation patterns in 2-vehicle collisions involving an AV and a CV, considering their interactions.
Infect Drug Resist
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Tuberculosis Diagnosis and Treatment Center, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang Province, People's Republic of China.
Background: Immune checkpoint inhibitors (ICIs) have emerged as the first-line treatment for driver-negative advanced non-small cell lung cancer (NSCLC). However, there is uncertainty regarding the availability and timing of ICI initiation in patients with NSCLC combined with pulmonary tuberculosis (TB). Additionally, the implementation of dual therapy for anti-TB and anti-tumor treatment poses significant challenges in terms of avoiding drug-drug interactions and reducing adverse reactions during clinical diagnosis and treatment.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China; Beijing Institute of Radiation Medicine, Beijing 100850, China; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address:
Neuroinflammation is a key driver of neurological disorders. Evodiamine (EVO), an alkaloid from the traditional Chinese herb Evodia rutaecarpa, possesses potent biological activities, notably anticancer and anti-inflammatory effects. This study investigates EVO's potential to attenuate LPS-induced neuroinflammation, focusing on identifying its therapeutic targets and mechanisms of action.
View Article and Find Full Text PDFJ Wound Care
January 2025
Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Clinical Research Centre, Singapore.
Objective: There is little use of maggot debridement therapy (MDT) worldwide, albeit there is much literature supporting its benefits and effectiveness for hard-to-heal (chronic) wounds. Hard-to-heal wounds are becoming ever more prevalent and MDT can play a pivotal role in wound care management. This underuse can be associated with patients' perceptions and experiences of MDT.
View Article and Find Full Text PDFAccid Anal Prev
January 2025
USDOT Center for Advanced Multimodal Mobility Solutions and Education, United States; Department of Civil and Environmental Engineering, University of North Carolina at Charlotte, United States. Electronic address:
Speeding crashes remain high injury severities after the stay-at-home order in California, highlighting a need for further investigation into the fundamental cause of this increment. To systematically explore the temporal impacts of the stay-at-home order on speeding behaviors and the corresponding crash-injury outcomes, this study utilizes California-reported single-vehicle speeding crashes on freeways (access-controlled) and non-freeways (non-access-controlled) before, during, and after the order. Significant injury factors and in-depth heterogeneity across observations are identified by random parameter logit models with heterogeneity in means and variances.
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